A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis
Although acetaminophen (ApAP) is one of the most commonly used medicines worldwide, hepatotoxicity is a risk with overdose or in patients with compromised liver function. ApAP overdose is the most common cause of acute fulminant hepatic failure. Oxidation of ApAP to N-acetyl-p-benzoquinone imine (NA...
- Autores:
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Bogotá Jorge Tadeo Lozano
- Repositorio:
- Expeditio: repositorio UTadeo
- Idioma:
- eng
- OAI Identifier:
- oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/13109
- Acceso en línea:
- https://www.sciencedirect.com/science/article/pii/S0223523420305729?via%3Dihub
http://hdl.handle.net/20.500.12010/13109
https://doi.org/10.1016/j.ejmech.2020.112600
- Palabra clave:
- Novel acetaminophen/paracetamol analogs
Hepatotoxicity
Analgesia
Antipyresis
APAP-induced liver injury (AILI)
Drug-drug interaction (DDI)
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
- Rights
- License
- Acceso restringido