Crystal structure, quantum chemical insights, and molecular docking studies of Naryl-2-(N-disubstituted) acetamide compounds: potential inhibitors for neurodegenerative enzymes

The increase in and concern about neurodegenerative diseases continue to grow in an increasingly long-lived world population. Therefore, the search for new drugs continues to be a priority for medicinal chemistry. We present here the synthesis of a series of compounds with acetamide nuclei. Their st...

Full description

Autores:

Camargo-Ayala, Lorena
Bedoya, Mauricio
Prent-Peñaloza, Luis
Polo-Cuadrado, Efraín
Osorio Lopez, Edison Humberto
Brito, Iván
Delgado, Gerzon E.
González, Wendy
Gutierrez, Margarita

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Ibagué

Repositorio:

Repositorio Universidad de Ibagué

Idioma:

eng

OAI Identifier:

oai:repositorio.unibague.edu.co:20.500.12313/5800

Acceso en línea:

https://hdl.handle.net/20.500.12313/5800
https://pubs.rsc.org/en/content/articlelanding/2024/ra/d3ra08649f

Palabra clave:

Estructura cristalina
Binding energy
Crystal structure
Free energy
Neurodegenerative diseases
Quantum chemistry

Rights

openAccess

License

© 2024 The Royal Society of Chemistry.