The interaction between amyloid prefibrillar oligomers of salmon calcitonin and a lipid-raft model: molecular mechanisms leading to membrane damage, Ca2+-Influx and neurotoxicity

ABSTRACT: To investigate the interaction between amyloid assemblies and “lipid-rafts”, we performed functional and structural experiments on salmon calcitonin (sCT) solutions rich in prefibrillar oligomers, proto- and mature-fibers interacting with liposomes made of monosialoganglioside-GM1 (4%), DP...

Full description

Autores:

Giordani Giordani, Cristiano
Diociaiuti, Marco
Bombelli, Cecilia
Zanetti Polzi, Laura
Belfiore, Marcello
Fioravanti, Raoul
Macchia, Gianfranco

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/39534

Acceso en línea:

https://hdl.handle.net/10495/39534

Palabra clave:

Amiloide
Amyloid
Animales
Animals
Calcitonina - química
Calcitonin - chemistry
Calcitonina - toxicidad
Calcitonin - toxicity
Calcio - metabolismo
Calcium - metabolism
Diferenciación Celular - efectos de los fármacos
Cell Differentiation - drug effects
Línea Celular
Cell Line
Supervivencia Celular - efectos de los fármacos
Cell Survival - drug effects
Interacciones Hidrofóbicas e Hidrofílicas
Hydrophobic and Hydrophilic Interactions
Microdominios de Membrana
Membrane Microdomains
Ratones
Mice
Modelos Biológicos
Models, Biological
Neuronas
Neurons
https://id.nlm.nih.gov/mesh/D000682
https://id.nlm.nih.gov/mesh/D000818
https://id.nlm.nih.gov/mesh/D002116
https://id.nlm.nih.gov/mesh/D002118
https://id.nlm.nih.gov/mesh/D002454
https://id.nlm.nih.gov/mesh/D002460
https://id.nlm.nih.gov/mesh/D002470
https://id.nlm.nih.gov/mesh/D057927
https://id.nlm.nih.gov/mesh/D021962
https://id.nlm.nih.gov/mesh/D051379
https://id.nlm.nih.gov/mesh/D008954
https://id.nlm.nih.gov/mesh/D009474

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/