LRRK2 Kinase Inhibitor PF-06447475 Protects Drosophila melanogaster against Paraquat-Induced Locomotor Impairment, Life Span Reduction, and Oxidative Stress

ABSTRACT: Parkinson’s disease (PD) is a complex multifactorial progressive neurodegenerative disease characterized by locomotor alteration due to the specific deterioration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc). Mounting evidence shows that human LRRK2 (hLRRK...

Full description

Autores:

Quintero Espinosa, Diana Alejandra
Jiménez del Río, Marlene
Vélez Pardo, Carlos Alberto

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/39784

Acceso en línea:

https://hdl.handle.net/10495/39784

Palabra clave:

Drosophila
Paraquat
Estrés Oxidativo
Oxidative Stress
Inhibidores de Proteínas Quinasas
Protein Kinase Inhibitors
Enfermedad de Parkinson
Parkinson Disease
https://id.nlm.nih.gov/mesh/D004330
https://id.nlm.nih.gov/mesh/D010269
https://id.nlm.nih.gov/mesh/D018384
https://id.nlm.nih.gov/mesh/D047428
https://id.nlm.nih.gov/mesh/D010300

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/