Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids

We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanocidal) of six quinoline-chalcone and five quinoline-chromone hybrids. The synthesized compounds were evaluated against amastigotes forms of L. (V) panamensis which is the most prevalent Leishmania speci...

Full description

Autores:

Coa Acuña, Juan Carlos
García Carvajal, Elisa
Agut, Raúl
Vélez Bernal, Iván Darío
Muñoz Usuga, July Andrea
Yepes Daza, Lina Marcela
Robledo Restrepo, Sara María
Cardona Galeano, Wilson
Carda, Miguel

Tipo de recurso:

Article of investigation

Fecha de publicación:

2017

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/46360

Acceso en línea:

https://hdl.handle.net/10495/46360

Palabra clave:

Enfermedad de Chagas
Chagas Disease
Leishmaniasis
Antiprotozoarios
Antiprotozoal Agents
Chalcona
Chalcone
Quinolinas
Quinolines
Trypanosoma cruzi - efectos de los fármacos
Trypanosoma cruzi - drug effects
Relación Estructura-Actividad
Structure-Activity Relationship
https://id.nlm.nih.gov/mesh/D014355
https://id.nlm.nih.gov/mesh/D007896
https://id.nlm.nih.gov/mesh/D000981
https://id.nlm.nih.gov/mesh/D002599
https://id.nlm.nih.gov/mesh/D011804
https://id.nlm.nih.gov/mesh/D014349
https://id.nlm.nih.gov/mesh/D013329
ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-sa/4.0/