The Structural Modeling of the Interaction between Levofloxacin and the Mycobacterium tuberculosis Gyrase Catalytic Site Sheds Light on the Mechanisms of Fluoroquinolones Resistant Tuberculosis in Colombian Clinical Isolates

ABSTRACT: We compared the prevalence of levofloxacin (LVX) resistance with that of ofloxacin (OFX) and moxifloxacin (MFX) among multidrug resistant (MDR) MTB clinical isolates collected in Medellin, Colombia, between 2004 and 2009 and aimed at unraveling the underlying molecular mechanisms that expl...

Full description

Autores:

Peláez Jaramillo, Carlos Alberto
Álvarez Zuluaga, Nataly
Zapata, E.
Mejía, G.I
Realpe, T.
Araque Marín, Predonel
Rouzaud, F.
Robledo, J.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2014

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/35210

Acceso en línea:

https://hdl.handle.net/10495/35210

Palabra clave:

Sustitución de Aminoácidos
Amino Acid Substitution
Antibacterianos
Anti-Bacterial Agents
Proteínas Bacterianas
Bacterial Proteins
Dominio Catalítico
Catalytic Domain
Farmacorresistencia Bacteriana Múltiple
Drug Resistance, Multiple, Bacterial
Levofloxacino
Levofloxacin
Mycobacterium tuberculosis
Tuberculosis Resistente a Múltiples Medicamentos
Tuberculosis, Multidrug-Resistant

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/