Potential of matrix metalloproteinase inhibitors for the treatment of local tissue damage induced by a type P-I snake venom metalloproteinase

ABSTRACT: Snake bite envenoming is a public health problem that was recently included in the list of neglected tropical diseases of the World Health Organization. In the search of new therapies for the treatment of local tissue damage induced by snake venom metalloproteinases (SVMPs), we tested the...

Full description

Autores:

Preciado Rojo, Lina María
Pereañez Jiménez, Jaime Andrés
Comer, Jeffrey

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41067

Acceso en línea:

https://hdl.handle.net/10495/41067

Palabra clave:

Bothrops
Venenos de Crotálidos - enzimología
Crotalid Venoms - enzymology
Venenos de Crotálidos - toxicidad
Crotalid Venoms - toxicity
Edema - inducido químicamente
Edema - chemically induced
Edema - prevención & control
Edema - prevention & control
Hemorragia - inducido químicamente
Hemorrhage - chemically induced
Hemorragia - prevención & control
Hemorrhage - prevention & control
Ácidos Hidroxámicos - química
Hydroxamic Acids - chemistry
Ácidos Hidroxámicos - farmacología
Hydroxamic Acids - pharmacology
Inhibidores de la Metaloproteinasa de la Matriz - uso terapéutico
Matrix Metalloproteinase Inhibitors - therapeutic use
Metaloproteasas - toxicidad
Metalloproteases - toxicity
Ratones
Mice
Modelos Moleculares
Models, Molecular
Simulación de Dinámica Molecular
Molecular Dynamics Simulation
Peptidomiméticos - uso terapéutico
Peptidomimetics - therapeutic use
Fosfolipasas A2 - toxicidad
Phospholipases A2 - toxicity
Inhibidores de Proteasas - farmacología
Protease Inhibitors - pharmacology
Inhibidores de Proteasas - uso terapéutico
Protease Inhibitors - therapeutic use
Mordeduras de Serpientes - tratamiento farmacológico
Snake Bites - drug therapy
Mordeduras de Serpientes - patología
Snake Bites - pathology
Zinc - química
Zinc - chemistry
Zinc - farmacología
Zinc - pharmacology
https://id.nlm.nih.gov/mesh/D017837
https://id.nlm.nih.gov/mesh/D003435
https://id.nlm.nih.gov/mesh/D004487
https://id.nlm.nih.gov/mesh/D006470
https://id.nlm.nih.gov/mesh/D006877
https://id.nlm.nih.gov/mesh/D061965
https://id.nlm.nih.gov/mesh/D045726
https://id.nlm.nih.gov/mesh/D051379
https://id.nlm.nih.gov/mesh/D008958
https://id.nlm.nih.gov/mesh/D056004
https://id.nlm.nih.gov/mesh/D057786
https://id.nlm.nih.gov/mesh/D054467
https://id.nlm.nih.gov/mesh/D011480
https://id.nlm.nih.gov/mesh/D012909
https://id.nlm.nih.gov/mesh/D015032

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/