Association of GWAS Top Genes With Late-Onset Alzheimer’s Disease in Colombian Population

ABSTRACT: Objective: The association of variants in CLU, CR1, PICALM, BIN1, ABCA7, and CD33 genes with late-onset Alzheimer’s disease (LOAD) was evaluated and confirmed through genome-wide association study. However, it is unknown whether these associations can be replicated in admixed populations. Methods: The association of 14 single-nucleotide polymorphisms in those genes was evaluated in 280 LOAD cases and 357 controls from the Colombian population. Results: In a multivariate analysis using age, gender, APOEe4 status, and admixture covariates, significant associations were obtained (P < .05) for variants in BIN1 (rs744373, odds ratio [OR]: 1.42), CLU (rs11136000, OR: 0.66), PICALM (rs541458, OR: 0.69), ABCA7 (rs3764650, OR: 1.7), and CD33 (rs3865444, OR: 1.12). Likewise, a significant interaction effect was observed between CLU and CR1 variants with APOE. Conclusion: This study replicated the associations previously reported in populations of European ancestry and shows that APOE variants have a regulatory role on the effect that variants in other loci have on LOAD, reflecting the importance of gene–gene interactions in the etiology of neurodegenerative diseases.

• Autores: Moreno García, Diana Jennifer; Ruíz Mendoza, Susana; Ríos Gallardo, Angela Magnolia; Lopera Restrepo, Francisco Javier; Ostos Alfonso, Henry; Marc Via, Marc; Bedoya Berrío, Gabriel de Jesús
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2017
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: spa
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/26742
• Acceso en línea: http://hdl.handle.net/10495/26742
• Palabra clave: Polymorphism Genetic; Polimorfismo Genético; Enfermedad de Alzheimer; Alzheimer Disease; Genética; Genetics
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/