Protein Predictive Modeling and Simulation of Mutations of Presenilin-1 Familial Alzheimer's Disease on the Orthosteric Site
ABSTRACT: Alzheimer's disease pathology is characterized by β-amyloid plaques and neurofibrillary tangles. Amyloid precursor protein is processed by β and γ secretase, resulting in the production of β-amyloid peptides with a length ranging from 38 to 43 amino acids. Presenilin 1 (PS1) is the ca...
- Autores:
-
Soto Ospina, Johnny Alejandro
Bedoya Berrío, Gabriel de Jesús
Sepúlveda Falla, Diego Alonso
Villegas Lanau, Carlos Andrés
Araque Marín, Pedronel
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/41094
- Acceso en línea:
- https://hdl.handle.net/10495/41094
- Palabra clave:
- Enfermedad de Alzheimer
Alzheimer Disease
Presenilina-1
Presenilin-1
https://id.nlm.nih.gov/mesh/D000544
https://id.nlm.nih.gov/mesh/D053764
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/