Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

ABSTRACT: Germline mutations in CYBB, the human gene encoding the gp91(phox) subunit of the phagocyte NADPH oxidase, impair the respiratory burst of all types of phagocytes and result in X-linked chronic granulomatous disease (CGD). We report here two kindreds in which otherwise healthy male adults...

Full description

Autores:

Arias Sierra, Andrés Augusto
Bustamante, Jacinta
Vogt, Guillaume
Picard, Capucine
Blancas Galicia, Lizbeth
Prando Andrade, Carolina
Virginia Grant, Audrey
Marchal, Christophe C
Hubeau, Marjorie
Chapgier, Ariane
de Beaucoudrey, Ludovic
Puel, Anne
Feinberg, Jacqueline
Valinetz, Ethan
Jannière, Lucile
Besse, Céline
Boland, Anne
Brisseau, Jean Marie
Blanche, Stéphane
Lortholary, Olivier
Fieschi, Claire
Emile, Jean François
Boisson Dupuis, Stéphanie
Al-Muhsen, Saleh
Woda, Bruce
Newburger, Peter E.
Condino Neto, Antonio
Dinauer, Mary C.
Abel, Laurent
Casanova, Jean Laurent

Tipo de recurso:

Article of investigation

Fecha de publicación:

2011

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/36591

Acceso en línea:

https://hdl.handle.net/10495/36591

Palabra clave:

Células CHO
CHO Cells
Cricetinae
Tuberculosis Ganglionar
Tuberculosis, Lymph Node
Genes Ligados a X
Genes, X-Linked
Macrófagos
Macrophages
Glicoproteínas de Membrana
Membrane Glycoproteins
NADPH Oxidasa 2
NADPH Oxidase 2
Tuberculosis

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/