PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans

ABSTRACT: Dental morphology varies greatly throughout evolution, including in the human lineage, but little is known about the biology of this variation. Here, we use multiomics analyses to examine the genetics of variation in tooth crown dimensions. In a human cohort with mixed continental ancestry...

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Autores:

Ramírez Aristeguieta, Luis Miguel
Delgado Burbano, Miguel Eduardo
Rojas Montoya, Winston
Ruiz Linares, Andrés
Li, Qing
Faux, Pierre
Yang, Guangrui
Chen, Yingjie
Fuentes Guajardo, Macarena
Poloni, Lauriane
Winchester, Emma Wentworth
Steimetz, Emilie
Gonzalez Jose, Rolando
Acuña, Victor
Cátira Bortolini, Maria
Poletti, Giovanni
Gallo, Carla
Rothhammer, Francisco
Zheng, Youyi
Cox, James C.
Patel, Vaishali
Hoffman, Matthew P.
Ding, Li
Peng, Chenchen
Cotney, Justin
Navarro, Nicolas
Cox, Timothy C.
Adhikari, Kaustubh

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/45157

Acceso en línea:

https://hdl.handle.net/10495/45157

Palabra clave:

Evolución Biológica
Biological Evolution
Receptor Edar
Edar Receptor
Introgresión Genética
Genetic Introgression
Estudio de Asociación del Genoma Completo
Genome-Wide Association Study
Proteína del Homeodomínio PITX2
Homeobox Protein PITX2
Proteínas de Homeodominio
Homeodomain Proteins
Hombre de Neandertal
Neanderthals
Polimorfismo de Nucleótido Simple
Polymorphism, Single Nucleotide
Diente
Tooth
Factores de Transcripción
Transcription Factors
https://id.nlm.nih.gov/mesh/D005075
https://id.nlm.nih.gov/mesh/D053339
https://id.nlm.nih.gov/mesh/D000079425
https://id.nlm.nih.gov/mesh/D055106
https://id.nlm.nih.gov/mesh/D000097577
https://id.nlm.nih.gov/mesh/D018398
https://id.nlm.nih.gov/mesh/D059125
https://id.nlm.nih.gov/mesh/D020641
https://id.nlm.nih.gov/mesh/D014070
https://id.nlm.nih.gov/mesh/D014157

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/2.5/co/