TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways

ABSTRACT: Acute lymphoblastic leukemia is still an incurable disease with resistance to therapy developing in the majority of patients. We investigated the effect of TPEN, an intracellular zinc chelator, in Jurkat and in ex vivo acute lymphoblastic leukemia (ALL) cells resistant to chemotherapy. Cha...

Full description

Autores:

Mendivil Pérez, Miguel Ángel
Jiménez del Río, Marlene
Vélez Pardo, Carlos Alberto

Tipo de recurso:

Article of investigation

Fecha de publicación:

2012

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/38546

Acceso en línea:

https://hdl.handle.net/10495/38546

Palabra clave:

Acetilcisteína - farmacología
Acetylcysteine - pharmacology
Apoptosis
Caspase 3
Núcleo Celular
Cell Nucleus
Relación Dosis-Respuesta a Droga
Dose-Response Relationship, Drug
Peróxido de Hidrógeno
Hydrogen Peroxide
Leucemia-Linfoma Linfoblástico de Células Precursoras
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Potencial de la Membrana Mitocondrial - efectos de los fármacos
Membrane Potential, Mitochondrial - drug effects
Membrane Potential, Mitochondrial - drug effects
https://id.nlm.nih.gov/mesh/D000111
https://id.nlm.nih.gov/mesh/D017209
https://id.nlm.nih.gov/mesh/D053148
https://id.nlm.nih.gov/mesh/D002467
https://id.nlm.nih.gov/mesh/D004305
https://id.nlm.nih.gov/mesh/D006861
https://id.nlm.nih.gov/mesh/D054198
https://id.nlm.nih.gov/mesh/D053078

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/