Even apparently insignificant chemical deviations among bioequivalent generic antibiotics can lead to therapeutic nonequivalence: the case of meropenem

ABSTRACT: Several studies with animal models have demonstrated that bioequivalence of generic products of antibiotics like vancomycin, as currently defined, do not guarantee therapeutic equivalence. However, the amounts and characteristics of impurities and degradation products in these formulations...

Full description

Autores:

Agudelo Pérez, María
Rodríguez Jaramillo, Carlos Andrés
Peláez Jaramillo, Carlos Alberto
Vesga Meneses, Omar

Tipo de recurso:

Article of investigation

Fecha de publicación:

2014

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/44330

Acceso en línea:

https://hdl.handle.net/10495/44330

Palabra clave:

Anti-Bacterial Agents
Antibacterianos
Biotransformation
Biotransformación
Brain
Encéfalo
Cilastatin
Cilastatina
Dipeptidases
Dipeptidasas
Preparaciones Farmacéuticas
Pharmaceutical Preparations
Guinea Pigs
Cobayas
Klebsiella Infections
Infecciones por Klebsiella
Lung
Pulmón
Meropenem
Mice
Ratones
Microbial Sensitivity Tests
Pruebas de Sensibilidad Microbiana
Muscle
Músculos
Protease Inhibitors
Inhibidores de Proteasas
Pseudomonas
Therapeutic Equivalency
Equivalencia Terapéutica
Thienamycins
Tienamicinas
Thigh
Muslo
Treatment Outcome
Resultado del Tratamiento
Anti-Bacterial Agents
Antibacterianos
https://id.nlm.nih.gov/mesh/D000900
https://id.nlm.nih.gov/mesh/D001711
https://id.nlm.nih.gov/mesh/D001921
https://id.nlm.nih.gov/mesh/D015377
https://id.nlm.nih.gov/mesh/D004150
https://id.nlm.nih.gov/mesh/D004364
https://id.nlm.nih.gov/mesh/D006168
https://id.nlm.nih.gov/mesh/D007710
https://id.nlm.nih.gov/mesh/D008168
https://id.nlm.nih.gov/mesh/D000077731
https://id.nlm.nih.gov/mesh/D051379
https://id.nlm.nih.gov/mesh/D008826
https://id.nlm.nih.gov/mesh/D009132
https://id.nlm.nih.gov/mesh/D011480
https://id.nlm.nih.gov/mesh/D011549
https://id.nlm.nih.gov/mesh/D013810
https://id.nlm.nih.gov/mesh/D013845
https://id.nlm.nih.gov/mesh/D013848
https://id.nlm.nih.gov/mesh/D016896

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/