Combinational Effect of CYP3A5 and MDR-1 Polymorphisms on Tacrolimus Pharmacokinetics in Liver Transplant Patients.

ABSTRACT: Objectives: Previous studies have reported reduced tacrolimus dose-adjusted exposure in individuals expressing the CYP3A5*1 allele (reference single nucleotide polymorphism identification number 776746). However, results on patients from South America are scarce. The objective of this stud...

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Autores:

Buendía Rodríguez, Jefferson Antonio
Otamendi, Esteban
Kravetz, María Cecilia
Cairo, Fernando
Ruf, Andrés
de Davila, María
Powazniak, Yanina
Nafissi, Julieta
Lazarowski, Alberto
Bramuglia, Guillermo
Villamil, Federico

Tipo de recurso:

Article of investigation

Fecha de publicación:

2015

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/42099

Acceso en línea:

https://hdl.handle.net/10495/42099

Palabra clave:

Subfamilia B de Transportador de Casetes de Unión a ATP
ATP Binding Cassette Transporter, Subfamily B
Argentina
Biotransformación
Biotransformation
Citocromo P-450 CYP3A
Cytochrome P-450 CYP3A
Preparaciones de Acción Retardada
Delayed-Action Preparations
Esquema de Medicación
Drug Administration Schedule
Monitoreo de Drogas
Drug Monitoring
Frecuencia de los Genes
Gene Frequency
Inmunosupresores
Immunosuppressive Agents
Trasplante de Hígado
Liver Transplantation
Tacrolimus
https://id.nlm.nih.gov/mesh/D018435
https://id.nlm.nih.gov/mesh/D001118
https://id.nlm.nih.gov/mesh/D001711
https://id.nlm.nih.gov/mesh/D051544
https://id.nlm.nih.gov/mesh/D003692
https://id.nlm.nih.gov/mesh/D004334
https://id.nlm.nih.gov/mesh/D016903
https://id.nlm.nih.gov/mesh/D005787
https://id.nlm.nih.gov/mesh/D007166
https://id.nlm.nih.gov/mesh/D016031
https://id.nlm.nih.gov/mesh/D016559

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc-nd/4.0/