Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts

ABSTRACT: The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining 65% of the TST variability. Disregarding the host genetic background ma...

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Autores:
Arbeláez Montoya, María Patricia
Barrera Robledo, Luis Fernando
Henao Vanegas, Hanna Marisol
García Moreno, Luis Fernando
Cobat, Aurélie
Abel, Laurent
Schurr, Erwin
Alcaïs, Alexandre
Tipo de recurso:
Article of investigation
Fecha de publicación:
2012
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/36478
Acceso en línea:
https://hdl.handle.net/10495/36478
Palabra clave:
Prueba de Tuberculina
Tuberculin Test
Pruebas Cutáneas
Skin Tests
Inmunidad Adaptativa
Mycobacterium tuberculosis
Antecedentes Genéticos
Genetic Background
Diagnóstico
Diagnosis
Variación Genética
Genetic Variation
Tuberculosis Latente - diagnóstico
Latent Tuberculosis - diagnosis
Tuberculosis Latente - genética
Latent Tuberculosis - genetics
Tuberculosis Latente - inmunología
Latent Tuberculosis - immunology
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.title.spa.fl_str_mv Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts
title Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts
spellingShingle Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts
Prueba de Tuberculina
Tuberculin Test
Pruebas Cutáneas
Skin Tests
Inmunidad Adaptativa
Mycobacterium tuberculosis
Antecedentes Genéticos
Genetic Background
Diagnóstico
Diagnosis
Variación Genética
Genetic Variation
Tuberculosis Latente - diagnóstico
Latent Tuberculosis - diagnosis
Tuberculosis Latente - genética
Latent Tuberculosis - genetics
Tuberculosis Latente - inmunología
Latent Tuberculosis - immunology
title_short Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts
title_full Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts
title_fullStr Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts
title_full_unstemmed Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts
title_sort Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts
dc.creator.fl_str_mv Arbeláez Montoya, María Patricia
Barrera Robledo, Luis Fernando
Henao Vanegas, Hanna Marisol
García Moreno, Luis Fernando
Cobat, Aurélie
Abel, Laurent
Schurr, Erwin
Alcaïs, Alexandre
dc.contributor.author.none.fl_str_mv Arbeláez Montoya, María Patricia
Barrera Robledo, Luis Fernando
Henao Vanegas, Hanna Marisol
García Moreno, Luis Fernando
Cobat, Aurélie
Abel, Laurent
Schurr, Erwin
Alcaïs, Alexandre
dc.contributor.researchgroup.spa.fl_str_mv Epidemiología
dc.subject.decs.none.fl_str_mv Prueba de Tuberculina
Tuberculin Test
Pruebas Cutáneas
Skin Tests
Inmunidad Adaptativa
Mycobacterium tuberculosis
Antecedentes Genéticos
Genetic Background
Diagnóstico
Diagnosis
Variación Genética
Genetic Variation
Tuberculosis Latente - diagnóstico
Latent Tuberculosis - diagnosis
Tuberculosis Latente - genética
Latent Tuberculosis - genetics
Tuberculosis Latente - inmunología
Latent Tuberculosis - immunology
topic Prueba de Tuberculina
Tuberculin Test
Pruebas Cutáneas
Skin Tests
Inmunidad Adaptativa
Mycobacterium tuberculosis
Antecedentes Genéticos
Genetic Background
Diagnóstico
Diagnosis
Variación Genética
Genetic Variation
Tuberculosis Latente - diagnóstico
Latent Tuberculosis - diagnosis
Tuberculosis Latente - genética
Latent Tuberculosis - genetics
Tuberculosis Latente - inmunología
Latent Tuberculosis - immunology
description ABSTRACT: The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining 65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2023-08-31T19:13:16Z
dc.date.available.none.fl_str_mv 2023-08-31T19:13:16Z
dc.type.spa.fl_str_mv Artículo de investigación
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
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dc.identifier.citation.spa.fl_str_mv Cobat A, Barrera Robledo LF, Henao Vanegas HM, Arbeláez Montoya MP, Abel L, García Moreno LF, et al. Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts. Clin Infect Dis [Internet]. 2012 [citado día mes año];54(7):968-71. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22291100/
dc.identifier.issn.none.fl_str_mv 1058-4838
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/36478
dc.identifier.doi.none.fl_str_mv 10.1093/cid/cir972
dc.identifier.eissn.none.fl_str_mv 1537-6591
identifier_str_mv Cobat A, Barrera Robledo LF, Henao Vanegas HM, Arbeláez Montoya MP, Abel L, García Moreno LF, et al. Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts. Clin Infect Dis [Internet]. 2012 [citado día mes año];54(7):968-71. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22291100/
1058-4838
10.1093/cid/cir972
1537-6591
url https://hdl.handle.net/10495/36478
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Clin. Infect. Dis.
dc.relation.citationendpage.spa.fl_str_mv 971
dc.relation.citationissue.spa.fl_str_mv 7
dc.relation.citationstartpage.spa.fl_str_mv 968
dc.relation.citationvolume.spa.fl_str_mv 54
dc.relation.ispartofjournal.spa.fl_str_mv Clinical Infectious Diseases
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.publisher.spa.fl_str_mv Oxford University Press
dc.publisher.place.spa.fl_str_mv Chicago, Estados Unidos
institution Universidad de Antioquia
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spelling Arbeláez Montoya, María PatriciaBarrera Robledo, Luis FernandoHenao Vanegas, Hanna MarisolGarcía Moreno, Luis FernandoCobat, AurélieAbel, LaurentSchurr, ErwinAlcaïs, AlexandreEpidemiología2023-08-31T19:13:16Z2023-08-31T19:13:16Z2012Cobat A, Barrera Robledo LF, Henao Vanegas HM, Arbeláez Montoya MP, Abel L, García Moreno LF, et al. Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household Contacts. Clin Infect Dis [Internet]. 2012 [citado día mes año];54(7):968-71. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22291100/1058-4838https://hdl.handle.net/10495/3647810.1093/cid/cir9721537-6591ABSTRACT: The tuberculin skin test (TST) measures the intensity of antimycobacterial acquired immunity and is used to diagnose latent infection with Mycobacterium tuberculosis. We report evidence for a codominant gene explaining 65% of the TST variability. Disregarding the host genetic background may lead to misclassifications of TST-based diagnosis of latent M. tuberculosis infection.Colombia. Ministerio de Ciencia, Tecnología e InnovaciónCanadian Institutes of Health ResearchCOL00043624application/pdfengOxford University PressChicago, Estados Unidoshttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Tuberculin Skin Test Reactivity is Dependent on Host Genetic Background in Colombian Tuberculosis Household ContactsArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPrueba de TuberculinaTuberculin TestPruebas CutáneasSkin TestsInmunidad AdaptativaMycobacterium tuberculosisAntecedentes GenéticosGenetic BackgroundDiagnósticoDiagnosisVariación GenéticaGenetic VariationTuberculosis Latente - diagnósticoLatent Tuberculosis - diagnosisTuberculosis Latente - genéticaLatent Tuberculosis - geneticsTuberculosis Latente - inmunologíaLatent Tuberculosis - immunologyClin. Infect. 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