Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths

ABSTRACT: Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lo...

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Autores:
Franco Restrepo, José Luis
Bastard, Paul
Gervais, Adrian
Le Voyer, Tom
Rosain, Jérémie
Philippot, Quentin
Manry, Jérémy
Michailidis, Eleftherios
Hoffmann, Hans Heinrich
Eto, Shohei
Garcia Prat, Marina
Bizien, Lucy
Parra Martínez, Alba
Yang, Rui
Haljasmägi, Liis
Migaud, Mélanie
Särekannu, Karita
Maslovskaja, Julia
de Prost, Nicolas
Tandjaoui Lambiotte, Yacine
Luyt, Charles Edouard
Amador Borrero, Blanca
Gaudet, Alexandre
Poissy, Julien
Morel, Pascal
Richard, Pascale
Cognasse, Fabrice
Troya, Jesus
Trouillet Assant, Sophie
Belot, Alexandre
Saker, Kahina
Garçon, Pierre
Rivière, Jacques
Lagier, Jean Christophe
Gentile, Stéphanie
Rosen, Lindsey B.
Shaw, Elana
Morio, Tomohiro
Tanaka, Junko
Dalmau, David
Tharaux, Pierre Louis
Sene, Damien
Stepanian, Alain
Megarbane, Bruno
Triantafyllia, Vasiliki
Fekkar, Arnaud
Heath, James R.
Anaya, Juan Manuel
Solé Violán, Jordi
Imberti, Luisa
Biondi, Andrea
Bonfanti, Paolo
Castagnoli, Riccardo
Delmonte, Ottavia M.
Zhang, Yu
Snow, Andrew L.
Holland, Steven M.
Biggs, Catherine
Moncada Vélez, Marcela
Arias Sierra, Andrés Augusto
Lorenzo, Lazaro
Boucherit, Soraya
Coulibaly, Boubacar
Anglicheau, Dany
Planas, Anna M
Haerynck, Filomeen
Duvlis, Sotirija
Nussbaum, Robert L.
Ozcelik, Tayfun
Keles, Sevgi
Bousfiha, Ahmed A.
El Bakkouri, Jalila
Ramírez Santana, Carolina
Paul, Stéphane
Pan Hammarström, Qiang
Hammarström, Lennart
Dupont, Annabelle
Kurolap, Alina
Metz, Christine N.
Aiuti, Alessandro
AlKhater, Suzan
Arrestier, Romain
Baris Feldman, Hagit
Barreiros, Lucila A.
Bilguvar, Kaya
Boyarchuk, Oksana
Bourke, Nollaig M.
Burrel, Sonia
Casari, Giorgio
Chauvineau Grenier, Angélique
Ciceri, Fabio
Condino Neto, Antonio
Coulongeat, Matthieu
Czerkowicz, Jakub
Darragh, Duffy
Domínguez Garrido, Elena
Dorgham, Karim
Dyer, Adam H.
Fellay, Jacques
Gilardin, Laurent
Hagin, David
Halwani, Rabih
Isabelle, Meyts
Joost, Wauters
Kann, Nelli Y
Karakaya, Mahmut
Klocperk, Adam
Lampasona, Vito
Lau, Yu Lung
Leung, Daniel
Lifton, Richard P.
Loreto, Vidaur
Lucie, Roussel
Marlet, Julien
Mehlal, Sedkaoui Souad
Nussenzweig, Michel C
Miyuki, Tsumura
Monneret, Guillaume
Morandeira, Francisco
Narjes Saheb, Sharif-Askari
Prando, Carolina
Quintana Murci, Lluis
Rigo Bonnin, Raúl
Reyes, Luis Felipe
Rye Ostrowski, Sisse
Saheb, Sharif-Askari Narjes
Sahanic, Sabina
Sallette, Jérome
Kennelly, Sean P.
Shcherbina, Anna
Shrikant, Mane
Spaan, András N.
Stepanovskyy, Yurii
Tangye, Stuart G
Tancevski, Ivan
Venet, Fabienne
Vidigal, Mateus
Vinh, Donald C.
Wauters, Joost
Nukui, Yoko
Tipo de recurso:
Article of investigation
Fecha de publicación:
2021
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/40974
Acceso en línea:
https://hdl.handle.net/10495/40974
Palabra clave:
Antibodies, Neutralizing
Anticuerpos Neutralizantes
Autoantibodies
Autoanticuerpos
COVID-19
Case-Control Studies
Estudios de Casos y Controles
Critical Illness
Enfermedad Crítica
Immunoglobulin G
Immunoglobulina G
Interferon Type I
Interferón Tipo I
Interferon-alpha
Interferón-alfa
Aged, 80 and over
Anciano de 80 o más Años
Middle Aged
Persona de Mediana Edad
https://id.nlm.nih.gov/mesh/D057134
https://id.nlm.nih.gov/mesh/D001323
https://id.nlm.nih.gov/mesh/D000086382
https://id.nlm.nih.gov/mesh/D016022
https://id.nlm.nih.gov/mesh/D016638
https://id.nlm.nih.gov/mesh/D007074
https://id.nlm.nih.gov/mesh/D007370
https://id.nlm.nih.gov/mesh/D007370
https://id.nlm.nih.gov/mesh/D016898
https://id.nlm.nih.gov/mesh/D000369
https://id.nlm.nih.gov/mesh/D008875
Rights
openAccess
License
https://creativecommons.org/licenses/by/4.0/