SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

ABSTRACT: The deployment of effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID-19) pandemic. Many licensed vaccines confer protection by inducing long-lived plasma cells (LLPCs) and memory B cells (MBCs...

Full description

Autores:

Castaño Monsalve, Diana María
Lederer, Katlyn
Gómez Atria, Daniela
Oguin III, Thomas H.
Sidney, Wang
Tomaz B., Manzoni
Muramatsu, Hiromi
Hogan, Michael J.
Amanat, Fatima
Cherubin, Patrick
Lundgreen, Kendall A.
Tam, Ying K
Steven H.Y., Fan
Laurence C., Eisenlohr
Maillard, Ivan
Weissman, Drew
Bates, Paul
Krammer, Florian
Sempowsk, Gregory D.
Pardi, Norbert
Locci, Michela

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/42018

Acceso en línea:

https://hdl.handle.net/10495/42018

Palabra clave:

COVID-19
Anticuerpos Neutralizantes
Antibodies, Neutralizing
Antígenos Virales
Antigens, Viral
Linfocitos B
B-Lymphocytes
Células Cultivadas
Cells, Cultured
Centro Germinal
Germinal Center
Vacunas de ARNm
mRNA Vaccines
Epítopos
Epitopes
Activación de Linfocitos
Lymphocyte Activation
SARS-CoV-2
https://id.nlm.nih.gov/mesh/D000086382
https://id.nlm.nih.gov/mesh/D057134
https://id.nlm.nih.gov/mesh/D000956
https://id.nlm.nih.gov/mesh/D001402
https://id.nlm.nih.gov/mesh/D002478
https://id.nlm.nih.gov/mesh/D018858
https://id.nlm.nih.gov/mesh/D000087503
https://id.nlm.nih.gov/mesh/D000939
https://id.nlm.nih.gov/mesh/D008213
https://id.nlm.nih.gov/mesh/D000086402

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc-nd/4.0/