Insulin-like growth factor-1 prevents Aβ[25-35] / (H2O2)-induced apoptosis in lymphocytes by reciprocal NF-κB activation and p53 inhibition via PI3K-dependent pathway
ABSTRACT The role of insulin-like growth factor (IGF-1) as neural survival factor for the treatment of Alzheimer’s disease has recently gained attention. The present study shows that IGF-1 protects lymphocytes from (10, 30 mM) Ab[25–35] and (25, 50, 100mM) H2O2-induced apoptosis through NF-kB activa...
- Autores:
-
Jiménez del Río, Marlene
Vélez Pardo, Carlos Alberto
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2006
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/32449
- Acceso en línea:
- https://hdl.handle.net/10495/32449
https://www.tandfonline.com/doi/full/10.1080/08977190500361788?scroll=top&needAccess=true
- Palabra clave:
- Insulin-Like Growth Factor I
Factor I del Crecimiento Similar a la Insulina
Phosphatidylinositol 3-Kinases
Fosfatidilinositol 3-Quinasas
Apoptosis
Amyloid beta-Peptides
Péptidos beta-Amiloides
Hydrogen Peroxide
Peróxido de Hidrógeno
Tumor Suppressor Protein p53
Proteína p53 Supresora de Tumor
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/2.5/co/