Sulfur compounds as inhibitors of enzymatic activity of a snake venom phospholipase A2: benzyl 4-nitrobenzenecarbodithioate as a case of study

ABSTRACT: Snakebite is a neglected disease with a high impact in tropical and subtropical countries. Therapy based on antivenom has limited efficacy in local tissue damage caused by venoms. Phospholipases A2 (PLA2) are enzymes that abundantly occur in snake venoms and induce several systemic and loc...

Full description

Autores:

Henao Castañeda, Isabel Cristina
Pereañez Jiménez, Jaime Andrés
Preciado Rojo, Lina María
Jios, Jorge L.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/39536

Acceso en línea:

https://hdl.handle.net/10495/39536

Palabra clave:

Venenos de Crotálidos - química
Crotalid Venoms - chemistry
Crotalus
Simulación del Acoplamiento Molecular
Molecular Docking Simulation
Inhibidores de Fosfolipasa A2 - química
Phospholipase A2 Inhibitors - chemistry
Fosfolipasas A2 - química
Phospholipases A2 - chemistry
Proteínas de Reptiles - antagonistas & inhibidores
Reptilian Proteins - antagonists & inhibitors
Proteínas de Reptiles - química
Reptilian Proteins - chemistry
Compuestos de Azufre - química
Sulfur Compounds - chemistry
https://id.nlm.nih.gov/mesh/D003435
https://id.nlm.nih.gov/mesh/D017839
https://id.nlm.nih.gov/mesh/D062105
https://id.nlm.nih.gov/mesh/D064801
https://id.nlm.nih.gov/mesh/D054467
https://id.nlm.nih.gov/mesh/D030162
https://id.nlm.nih.gov/mesh/D013457

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/