Dmp53, Basket and drICE Gene Knockdown and Polyphenol Gallic Acid Increase Life Span and Locomotor Activity in a Drosophila Parkinson’s Disease Model

ABSTRACT: Understanding the mechanism(s) by which dopaminergic (DAergic) neurons are eroded in Parkinson's disease (PD) is critical for effective therapeutic strategies. By using the binary tyrosine hydroxylase (TH)-Gal4/UAS-X RNAi Drosophila melanogaster system, we report that Dmp53, basket an...

Full description

Autores:

Ortega Arellano, Hector Flavio
Jiménez del Río, Marlene
Vélez Pardo, Carlos Alberto

Tipo de recurso:

Article of investigation

Fecha de publicación:

2013

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/34005

Acceso en línea:

https://hdl.handle.net/10495/34005
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873193/

Palabra clave:

Drosophila
Paraquat
Parkinson Disease
Enfermedad de Parkinson
Polyphenols
Polifenoles
Longevity
Longevidad
Motor Activity
Actividad Motora

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/