Pharmacogenetic impact of VKORC1 and CYP2C9 allelic variants on warfarin dose requirements in a hispanic population isolate

ABSTRACT: Warfarin is the most prescribed oral anticoagulant worldwide. Because of the complexity of warfarin therapy, we attempted to dissect genetic from bioenviron mental factors influencing warfarin dose responses in individuals of a genetic isolate of Hispanic ancestry. A total of 191 patients...

Full description

Autores:

Palacio Muñoz, Lina Marcela
Falla Avila, Diana Yanina
Tobón, Ignacio
Mejía Restrepo, Fernando Antonio
Lewis, John E.
Martínez, Ariel F.
Arcos Burgos, Oscar Mauricio
Camargo Guerrero, Mauricio

Tipo de recurso:

Article of investigation

Fecha de publicación:

2010

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41789

Acceso en línea:

https://hdl.handle.net/10495/41789

Palabra clave:

Anticoagulantes - administración y dosificación
Anticoagulants - administration and dosage
Anticoagulantes - farmacocinética
Anticoagulants - pharmacokinetics
Hidrocarburo de Aril Hidroxilasas
Aryl Hydrocarbon Hydroxylases
Colombia - epidemiología
Colombia - epidemiology
Citocromo P-450 CYP2C9
Cytochrome P-450 CYP2C9
Relación Dosis-Respuesta a Droga
Dose-Response Relationship, Drug
Etnicidad - estadística y datos numéricos
Ethnicity - statistics and numerical data
Frecuencia de los Genes
Gene Frequency
Variación Genética
Genetic Variation
Genotipo
Genotype
Oxigenasas de Función Mixta
Mixed Function Oxygenases
Trombosis
Thrombosis
Vitamina K Epóxido Reductasas
Vitamin K Epoxide Reductases
Warfarina
Warfarin
https://id.nlm.nih.gov/mesh/D000925
https://id.nlm.nih.gov/mesh/D001189
https://id.nlm.nih.gov/mesh/D003105
https://id.nlm.nih.gov/mesh/D065729
https://id.nlm.nih.gov/mesh/D004305
https://id.nlm.nih.gov/mesh/D005006
https://id.nlm.nih.gov/mesh/D005787
https://id.nlm.nih.gov/mesh/D014644
https://id.nlm.nih.gov/mesh/D005838
https://id.nlm.nih.gov/mesh/D006899
https://id.nlm.nih.gov/mesh/D013927
https://id.nlm.nih.gov/mesh/D064417
https://id.nlm.nih.gov/mesh/D014859

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc/2.5/co/