Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies

ABSTRACT: The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-...

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Autores:
Bedoya Berrio, Gabriel De Jesus
Ruiz Linares, Andrés
Service, Susan
Deyoung, Joseph
Karayiorgou, María
Pretoriuos, Herman
Bedoya, Gabriel
Ospina Duque, Jorge
Macedo, António
Palha, Joana Almeida
Heutink, Peter
Aulchenko, Yurii
Oostra, Ben
Van Duijn, Cornelia
Jarvelin, Marjo Riitta
Varilo, Teppo
Peddle, Lynette
Rahman, Proton
Murray, Sarah
Galver, Luana
Peltonen, Leena
Sabatti, Chiara
Collins, Andrew
Freimer, Nelson
Tipo de recurso:
Article of investigation
Fecha de publicación:
2006
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/36450
Acceso en línea:
https://hdl.handle.net/10495/36450
Palabra clave:
Cromosomas Humanos Par 22
Chromosomes, Human, Pair 22
Genética de Población
Genetics, Population
Genoma Humano
Genome, Human
Desequilibrio de Ligamiento
Linkage Disequilibrium
Polimorfismo de Nucleótido Simple
Polymorphism, Single Nucleotide
Rights
openAccess
License
https://creativecommons.org/licenses/by/4.0/
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oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/36450
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network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies
title Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies
spellingShingle Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies
Cromosomas Humanos Par 22
Chromosomes, Human, Pair 22
Genética de Población
Genetics, Population
Genoma Humano
Genome, Human
Desequilibrio de Ligamiento
Linkage Disequilibrium
Polimorfismo de Nucleótido Simple
Polymorphism, Single Nucleotide
title_short Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies
title_full Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies
title_fullStr Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies
title_full_unstemmed Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies
title_sort Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies
dc.creator.fl_str_mv Bedoya Berrio, Gabriel De Jesus
Ruiz Linares, Andrés
Service, Susan
Deyoung, Joseph
Karayiorgou, María
Pretoriuos, Herman
Bedoya, Gabriel
Ospina Duque, Jorge
Macedo, António
Palha, Joana Almeida
Heutink, Peter
Aulchenko, Yurii
Oostra, Ben
Van Duijn, Cornelia
Jarvelin, Marjo Riitta
Varilo, Teppo
Peddle, Lynette
Rahman, Proton
Murray, Sarah
Galver, Luana
Peltonen, Leena
Sabatti, Chiara
Collins, Andrew
Freimer, Nelson
dc.contributor.author.none.fl_str_mv Bedoya Berrio, Gabriel De Jesus
Ruiz Linares, Andrés
Service, Susan
Deyoung, Joseph
Karayiorgou, María
Pretoriuos, Herman
Bedoya, Gabriel
Ospina Duque, Jorge
Macedo, António
Palha, Joana Almeida
Heutink, Peter
Aulchenko, Yurii
Oostra, Ben
Van Duijn, Cornelia
Jarvelin, Marjo Riitta
Varilo, Teppo
Peddle, Lynette
Rahman, Proton
Murray, Sarah
Galver, Luana
Peltonen, Leena
Sabatti, Chiara
Collins, Andrew
Freimer, Nelson
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en Psiquiatría GIPSI
dc.subject.decs.none.fl_str_mv Cromosomas Humanos Par 22
Chromosomes, Human, Pair 22
Genética de Población
Genetics, Population
Genoma Humano
Genome, Human
Desequilibrio de Ligamiento
Linkage Disequilibrium
Polimorfismo de Nucleótido Simple
Polymorphism, Single Nucleotide
topic Cromosomas Humanos Par 22
Chromosomes, Human, Pair 22
Genética de Población
Genetics, Population
Genoma Humano
Genome, Human
Desequilibrio de Ligamiento
Linkage Disequilibrium
Polimorfismo de Nucleótido Simple
Polymorphism, Single Nucleotide
description ABSTRACT: The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.
publishDate 2006
dc.date.issued.none.fl_str_mv 2006
dc.date.accessioned.none.fl_str_mv 2023-08-30T13:46:33Z
dc.date.available.none.fl_str_mv 2023-08-30T13:46:33Z
dc.type.spa.fl_str_mv Artículo de investigación
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dc.identifier.citation.spa.fl_str_mv Service S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, Ospina J, Ruiz-Linares A, Macedo A, Palha JA, Heutink P, Aulchenko Y, Oostra B, van Duijn C, Jarvelin MR, Varilo T, Peddle L, Rahman P, Piras G, Monne M, Murray S, Galver L, Peltonen L, Sabatti C, Collins A, Freimer N. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet. 2006 May;38(5):556-60. doi: 10.1038/ng1770. Epub 2006 Apr 2. PMID: 16582909.
dc.identifier.issn.none.fl_str_mv 1061-4036
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/36450
dc.identifier.doi.none.fl_str_mv 10.1038/ng1770
dc.identifier.eissn.none.fl_str_mv 1546-1718
identifier_str_mv Service S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, Ospina J, Ruiz-Linares A, Macedo A, Palha JA, Heutink P, Aulchenko Y, Oostra B, van Duijn C, Jarvelin MR, Varilo T, Peddle L, Rahman P, Piras G, Monne M, Murray S, Galver L, Peltonen L, Sabatti C, Collins A, Freimer N. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet. 2006 May;38(5):556-60. doi: 10.1038/ng1770. Epub 2006 Apr 2. PMID: 16582909.
1061-4036
10.1038/ng1770
1546-1718
url https://hdl.handle.net/10495/36450
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Nat. Genet.
dc.relation.citationendpage.spa.fl_str_mv 560
dc.relation.citationissue.spa.fl_str_mv 5
dc.relation.citationstartpage.spa.fl_str_mv 556
dc.relation.citationvolume.spa.fl_str_mv 38
dc.relation.ispartofjournal.spa.fl_str_mv Nature Genetics
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dc.publisher.spa.fl_str_mv Nature Research
dc.publisher.place.spa.fl_str_mv Nueva York, Estados Unidos
institution Universidad de Antioquia
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spelling Bedoya Berrio, Gabriel De JesusRuiz Linares, AndrésService, SusanDeyoung, JosephKarayiorgou, MaríaPretoriuos, HermanBedoya, GabrielOspina Duque, JorgeMacedo, AntónioPalha, Joana AlmeidaHeutink, PeterAulchenko, YuriiOostra, BenVan Duijn, CorneliaJarvelin, Marjo RiittaVarilo, TeppoPeddle, LynetteRahman, ProtonMurray, SarahGalver, LuanaPeltonen, LeenaSabatti, ChiaraCollins, AndrewFreimer, NelsonGrupo de Investigación en Psiquiatría GIPSI2023-08-30T13:46:33Z2023-08-30T13:46:33Z2006Service S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, Ospina J, Ruiz-Linares A, Macedo A, Palha JA, Heutink P, Aulchenko Y, Oostra B, van Duijn C, Jarvelin MR, Varilo T, Peddle L, Rahman P, Piras G, Monne M, Murray S, Galver L, Peltonen L, Sabatti C, Collins A, Freimer N. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet. 2006 May;38(5):556-60. doi: 10.1038/ng1770. Epub 2006 Apr 2. PMID: 16582909.1061-4036https://hdl.handle.net/10495/3645010.1038/ng17701546-1718ABSTRACT: The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.COL00291475application/pdfengNature ResearchNueva York, Estados Unidoshttps://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studiesArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionCromosomas Humanos Par 22Chromosomes, Human, Pair 22Genética de PoblaciónGenetics, PopulationGenoma HumanoGenome, HumanDesequilibrio de LigamientoLinkage DisequilibriumPolimorfismo de Nucleótido SimplePolymorphism, Single NucleotideNat. 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