Release of Bioactive Peptides from Erythrina edulis (Chachafruto) Proteins under Simulated Gastrointestinal Digestion

ABSTRACT: The estimated and concerning rise in world population over the next few years and the consequent increase in food demand will lead to a deterioration in global food security. To avoid or reduce this world crisis, informed and empowered consumers are turning to sustainable and nutrient-rich foods that substitute animal products, also reducing their associated environmental impact. Moreover, due to the demonstrated influence of diet on the risk of high incidence and mortality of noncommunicable diseases, the current established food pattern is focused on the consumption of foods that have functionality for health. Among these new foods, traditional and underutilized plants are gaining interest as alternative protein sources providing nutritional and biological properties. In this work, the potential of Erythrina edulis (chachafruto) proteins as a source of multifunctional peptides after transit through the gastrointestinal tract has been demonstrated, with antioxidant and immunostimulating effects in both biochemical assays and cell culture. While low molecular weight peptides released during the digestive process were found to be responsible for protection against oxidative stress mediated by their radical scavenging activity, high molecular weight peptides exerted immunostimulating effects by upregulation of immunoresponse-associated biomarkers. The findings of this study support the promising role of chachafruto proteins as a new antioxidant and immunostimulatory ingredient for functional foods and nutraceuticals.

• Autores: Correa Caleno, Jessica Leonor; Zapata Montoya, José Edgar; Hernández Ledesma, Blanca
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2022
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/39528
• Acceso en línea: https://hdl.handle.net/10495/39528
• Palabra clave: Antioxidantes - metabolismo; Antioxidants - metabolism; Digestión; Digestion; Erythrina - química; Erythrina - chemistry; Erythrina - metabolismo; Erythrina - metabolism; Péptidos - química; Peptides - chemistry; Proteínas; Proteins; https://id.nlm.nih.gov/mesh/D000975; https://id.nlm.nih.gov/mesh/D004063; https://id.nlm.nih.gov/mesh/D004895; https://id.nlm.nih.gov/mesh/D010455; https://id.nlm.nih.gov/mesh/D011506
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/