Exposición a aflatoxina : un problema de salud pública
ABSTRACT: Aflatoxin, a mycotoxin produced by pollutant molds, is a potent hepatotoxic and carcinogenic agent. Dietary exposition to it is of particular importance in certain regions of Southeast Asia and sub-Saharan Africa. Populations in these regions suffer from high incidence of hepatocellular ca...
- Autores:
-
Carreño Venegas, Andrea Fernanda
Hurtado Guerra, Juan José
Navas Navas, María Cristina
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12918
- Acceso en línea:
- http://hdl.handle.net/10495/12918
- Palabra clave:
- Aflatoxina B1
Carcinoma Hepatocelular
Dieta
Factores de Riesgo
Neoplasias Hepáticas
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/2.5/co/
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Exposición a aflatoxina : un problema de salud pública |
| dc.title.translated.spa.fl_str_mv |
Exposition to aflatoxin : A public health problem |
| title |
Exposición a aflatoxina : un problema de salud pública |
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Exposición a aflatoxina : un problema de salud pública Aflatoxina B1 Carcinoma Hepatocelular Dieta Factores de Riesgo Neoplasias Hepáticas |
| title_short |
Exposición a aflatoxina : un problema de salud pública |
| title_full |
Exposición a aflatoxina : un problema de salud pública |
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Exposición a aflatoxina : un problema de salud pública |
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Exposición a aflatoxina : un problema de salud pública |
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Exposición a aflatoxina : un problema de salud pública |
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Carreño Venegas, Andrea Fernanda Hurtado Guerra, Juan José Navas Navas, María Cristina |
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Carreño Venegas, Andrea Fernanda Hurtado Guerra, Juan José Navas Navas, María Cristina |
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Grupo de Gastrohepatología |
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Aflatoxina B1 Carcinoma Hepatocelular Dieta Factores de Riesgo Neoplasias Hepáticas |
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Aflatoxina B1 Carcinoma Hepatocelular Dieta Factores de Riesgo Neoplasias Hepáticas |
| description |
ABSTRACT: Aflatoxin, a mycotoxin produced by pollutant molds, is a potent hepatotoxic and carcinogenic agent. Dietary exposition to it is of particular importance in certain regions of Southeast Asia and sub-Saharan Africa. Populations in these regions suffer from high incidence of hepatocellular carcinoma, and have high frequency of the mutation in the codon 249 of p53 gene; besides, prevalence of Hepatitis B virus (HBV) infection is high in those populations. Synergism between infection with HBV and the exposition to this mycotoxin in the pathogenesis of hepatocellular carcinoma has been demonstrated. Few studies have explored the exposition to aflatoxin in the diet of populations in Latin America, and the role in them of this mycotoxin as a risk factor for hepatocellular carcinoma is unknown. In this article different aspects of aflatoxin are reviewed with emphasis on its relationship with HBV infection and with such neoplasia. |
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Carreño Venegas AF, Hurtado Guerra JJ, Navas Navas MC. Exposición a aflatoxina: un problema de salud pública. Iatreia. 2014 Ene-Mar;27(1):42-52. |
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0121-0793 |
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2011-7965 |
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Carreño Venegas AF, Hurtado Guerra JJ, Navas Navas MC. Exposición a aflatoxina: un problema de salud pública. Iatreia. 2014 Ene-Mar;27(1):42-52. 0121-0793 2011-7965 |
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Carreño Venegas, Andrea FernandaHurtado Guerra, Juan JoséNavas Navas, María CristinaGrupo de Gastrohepatología2020-01-09T19:39:36Z2020-01-09T19:39:36Z2014Carreño Venegas AF, Hurtado Guerra JJ, Navas Navas MC. Exposición a aflatoxina: un problema de salud pública. Iatreia. 2014 Ene-Mar;27(1):42-52.0121-0793http://hdl.handle.net/10495/129182011-7965ABSTRACT: Aflatoxin, a mycotoxin produced by pollutant molds, is a potent hepatotoxic and carcinogenic agent. Dietary exposition to it is of particular importance in certain regions of Southeast Asia and sub-Saharan Africa. Populations in these regions suffer from high incidence of hepatocellular carcinoma, and have high frequency of the mutation in the codon 249 of p53 gene; besides, prevalence of Hepatitis B virus (HBV) infection is high in those populations. Synergism between infection with HBV and the exposition to this mycotoxin in the pathogenesis of hepatocellular carcinoma has been demonstrated. Few studies have explored the exposition to aflatoxin in the diet of populations in Latin America, and the role in them of this mycotoxin as a risk factor for hepatocellular carcinoma is unknown. In this article different aspects of aflatoxin are reviewed with emphasis on its relationship with HBV infection and with such neoplasia.RESUMEN: La aflatoxina, una micotoxina producida por hongos contaminantes, es un potente tóxico hepático y un agente carcinógeno. La exposición a ella en la dieta es de particular importancia en ciertas regiones del Sureste de Asia y de África subsahariana, cuyas poblaciones presentan alta frecuencia de carcinoma hepatocelular y de la mutación en el codón 249 del gen p53; además, tienen alta prevalencia de la infección por el virus de la hepatitis B. Este factor de riesgo es muy importante si se tiene en cuenta que se ha demostrado sinergia entre la infección por dicho virus y la exposición a aflatoxina en la patogénesis del carcinoma hepatocelular. Pocos estudios han explorado la exposición a aflatoxinas en la dieta de la población latinoamericana y se desconoce el papel en ella de esta micotoxina como factor de riesgo para dicho carcinoma. En este artículo se presenta una revisión sobre diversos aspectos de las aflatoxinas, con énfasis en su relación con la infección por el virus de la hepatitis B y con el carcinoma hepatocelular.52application/pdfspaUniversidad de Antioquia, Facultad de MedicinaMedellín, Colombiahttps://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Aflatoxina B1Carcinoma HepatocelularDietaFactores de RiesgoNeoplasias HepáticasExposición a aflatoxina : un problema de salud públicaExposition to aflatoxin : A public health problemArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionIatreia52127IatreiaPublicationORIGINALCarreñoAndrea_2014_ExposicionAflatoxinaSalud.pdfCarreñoAndrea_2014_ExposicionAflatoxinaSalud.pdfArtículo de revisiónapplication/pdf897520https://bibliotecadigital.udea.edu.co/bitstreams/6bc6a900-f3c5-4d99-a905-57dfaf6401b3/download7e9da5e54da7f3a089e330ec0c190129MD51trueAnonymousREADCC-LICENSElicense_urllicense_urltext/plain; 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