Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

ABSTRACT: We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value <5 × 10-8) at 42 genome regions, nine of which...

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Autores:

Jaramillo Alzate, Claudia Milena
Arias Pérez, William Hernán
Ruíz Linares, Andrés
Rojas Montoya, Winston
Faux, Pierre
Delgado, Miguel Eduardo
Bonfante, Betty
Fuentes Guajardo, Macarena
Mendoza Revilla, Javier
Chacón Duque, Juan Camilo
Hurtado, Malena
Villegas, Valeria
Granja, Vanessa
Barquera, Rodrigo
Everardo Martínez, Paola
Sánchez Quinto, Mirsha
Gómez Valdés, Jorge
Villamil Ramírez, Hugo
Silva de Cerqueira, Caio C.
Hünemeier, Tábita
Ramallo, Virginia
Wu, Sijie
Du, Siyuan
Giardina, Andrea
Subhra Paria, Soumya
Khokan, Mahfuzur Rahman
González José, Rolando
Schüler Faccini, Lavinia
Bortolini, María Cátira
Acuña Alonzo, Víctor
Canizales Quinteros, Samuel
Gallo, Carla
Poletti, Giovanni
Rothhammer, Francisco
Navarro, Nicolás
Wang, Sijia
Adhikari, Kaustubh
Chen, Jieyi
Li, Qing

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41002

Acceso en línea:

https://hdl.handle.net/10495/41002

Palabra clave:

Cell Differentiation
Diferenciación Celular
Genome-Wide Association Study
Estudio de Asociación del Genoma Completo
Neanderthals
Hombre de Neandertal
Nose
Nariz
https://id.nlm.nih.gov/mesh/D002454
https://id.nlm.nih.gov/mesh/D055106
https://id.nlm.nih.gov/mesh/D059125

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/