α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence

ABSTRACT: Background: Activated hepatic stellate cells (aHSCs) are the main effector cells during liver fibrogenesis. α-1 adrenergic antagonist doxazosin (DX) was shown to be anti-fibrotic in an in vivo model of liver fibrosis (LF), but the mechanism remains to be elucidated. Recent studies suggest...

Full description

Autores:

Arroyave Ospina, Johanna Carolina
Serna Salas, Sandra A.
Zhang, Mengfan
Damba, Turtushikh
Buist Homan, Manon
Muñoz Ortega, Martin H
Ventura Juárez, Javier
Moshage, Han

Tipo de recurso:

Article of investigation

Fecha de publicación:

2022

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/40152

Acceso en línea:

https://hdl.handle.net/10495/40152

Palabra clave:

Antagonistas de Receptores Adrenérgicos alfa 1
Adrenergic alpha-1 Receptor Antagonists
Agonistas alfa-Adrenérgicos
Adrenergic alpha-Agonists
Puntos de Control del Ciclo Celular
Cell Cycle Checkpoints
Proliferación Celular
Cell Proliferation
Células Cultivadas
Cells, Cultured
Senescencia Celular
Cellular Senescence
Doxazosina
Doxazosin
Células Estrelladas Hepáticas
Hepatic Stellate Cells
Cirrosis Hepática
Liver Cirrhosis
Norepinefrina
Norepinephrine
Receptores Adrenérgicos alfa 1
Receptors, Adrenergic, alpha-1
Fenotipo Secretor Asociado a la Senescencia
Senescence-Associated Secretory Phenotype
Transducción de Señal
Signal Transduction
Sulfonamidas
Sulfonamides
https://id.nlm.nih.gov/mesh/D008103
https://id.nlm.nih.gov/mesh/D058668
https://id.nlm.nih.gov/mesh/D000316
https://id.nlm.nih.gov/mesh/D059447
https://id.nlm.nih.gov/mesh/D049109
https://id.nlm.nih.gov/mesh/D002478
https://id.nlm.nih.gov/mesh/D016922
https://id.nlm.nih.gov/mesh/D017292
https://id.nlm.nih.gov/mesh/D055166
https://id.nlm.nih.gov/mesh/D009638
https://id.nlm.nih.gov/mesh/D018340
https://id.nlm.nih.gov/mesh/D000089262
https://id.nlm.nih.gov/mesh/D015398
https://id.nlm.nih.gov/mesh/D013449

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/