A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

ABSTRACT: SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high transmissibility of the virus and the high rate of morbidity and mortality associated with COVID-19, developing effective and safe vaccines is a top research priority. Here, we provide a detailed evaluation...

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Autores:

Castaño Monsalve, Diana María
Laczkó, Dorottya
Hogan, Michael J.
Toulmin, Sushila A.
Hicks, Philip
Lederer, Katlyn
Gaudette, Brian T.
Amanat, Fatima
Muramatsu, Hiromi
Oguin III, Thomas H.
Ojha, Amrita
Zhang, Lizhou
Mu, Zekun
Parks, Robert
Manzoni, Tomaz B.
Roper, Brianne
Strohmeier, Shirin
Tombácz, István
Arwood, Leslee
Nachbagauer, Raffael
Karikó, Katalin
Greenhouse, Jack
Pessaint, Laurent
Porto, Maciel
Putman Taylor, Tammy
Strasbaugh, Amanda
Campbell, Tracey Ann
Lin, Paulo J.C.
Tam, Ying K.
Sempowski, Gregory D.
Farzan, Michael
Choe, Hyeryun
Saunders, Kevin O.
Haynes, Barton F.
Andersen, Hanne
Eisenlohr, Laurence C.
Weissman, Drew
Krammer, Florian
Bates, Paul
Allman, David
LoccII, Michela
Pardi, Norbert

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/42022

Acceso en línea:

https://hdl.handle.net/10495/42022

Palabra clave:

COVID-19
Anticuerpos Neutralizantes
Antibodies, Neutralizing
Antígenos Virales
Antigens, Viral
Linfocitos B
B-Lymphocytes
Vacunas de ARNm
mRNA Vaccines
Betacoronavirus
Linfocitos T CD4-Positivos
CD4-Positive T-Lymphocytes
Linfocitos T CD8-positivos
CD8-Positive T-Lymphocytes
Vacunas contra la COVID-19
COVID-19 Vaccines
Infecciones por Coronavirus
Coronavirus Infections
Modelos Animales de Enfermedad
Disease Models, Animal
Furina
Furin
Inmunidad Humoral
Immunity, Humoral
Inmunogenicidad Vacunal
Immunogenicity, Vaccine
SARS-CoV-2
Activación de Linfocitos
Lymphocyte Activation
Pandemias
Pandemics
Neumonía Viral
Pneumonia, Viral
Glicoproteína de la Espiga del Coronavirus
Spike Glycoprotein, Coronavirus
https://id.nlm.nih.gov/mesh/D000086382
https://id.nlm.nih.gov/mesh/D057134
https://id.nlm.nih.gov/mesh/D000956
https://id.nlm.nih.gov/mesh/D002478
https://id.nlm.nih.gov/mesh/D000087503
https://id.nlm.nih.gov/mesh/D000073640
https://id.nlm.nih.gov/mesh/D015496
https://id.nlm.nih.gov/mesh/D018414
https://id.nlm.nih.gov/mesh/D000086663
https://id.nlm.nih.gov/mesh/D018352
https://id.nlm.nih.gov/mesh/D004195
https://id.nlm.nih.gov/mesh/D045683
https://id.nlm.nih.gov/mesh/D056724
https://id.nlm.nih.gov/mesh/D000071497
https://id.nlm.nih.gov/mesh/D000086402
https://id.nlm.nih.gov/mesh/D008213
https://id.nlm.nih.gov/mesh/D058873
https://id.nlm.nih.gov/mesh/D011024
https://id.nlm.nih.gov/mesh/D064370

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc-nd/2.5/co/