Diffusion Mechanism Modeling of Metformin in Human Organic Cationic Amino Acid Transporter one and Functional Impact of S189L, R206C, and G401S Mutation

ABSTRACT: Metformin used as a first-line drug to treat Type 2 Diabetes Mellitus is transported via organic cation channels to soft tissues. Mutations in the SLC22A1 gene, such as Gly401Ser, Ser189Leu, and Arg206Cys, may affect the drug's therapeutic effect on these patients. This study aims at...

Full description

Autores:

Cano Vásquez, Leidy Johana
Soto Ospina, Johnny Alejandro
Bedoya Berrío, Gabriel de Jesús
Caro Gómez, María Antonieta
Parra Marín, María Victoria
Duque Vélez, Constanza Elena
Araque Marín, Pedronel

Tipo de recurso:

Article of investigation

Fecha de publicación:

2021

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41100

Acceso en línea:

https://hdl.handle.net/10495/41100

Palabra clave:

Metformina
Metformin
Farmacogenética
Pharmacogenetics
Diabetes Mellitus Tipo 2
Diabetes Mellitus, Type 2
Mutación
Mutation
https://id.nlm.nih.gov/mesh/D008687
https://id.nlm.nih.gov/mesh/D010597
https://id.nlm.nih.gov/mesh/D003924
https://id.nlm.nih.gov/mesh/D009154

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/