Neanderthal introgression in SCN9A impacts mechanical pain sensitivity

ABSTRACT: The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBa...

Full description

Autores:

Ramírez Aristeguieta, Luis Miguel
Jaramillo Alzate, Claudia Milena
Arias Pérez, William Hernán
Rojas Montoya, Winston
Bennett, David L.
Bortolini, Maria Cátira
Canizales Quinteros, Samuel
Chacón Duque, Juan Camilo
Comini, Maddalena
Ding, Li
Everardo Martínez, Paola
Faux, Pierre
Fuentes Guajardo, Macarena
Gallo, Carla
Gómez Valdés, Jorge
González José, Rolando
Granja, Vanessa
Hünemeier, Tábita
Hurtado, Malena
Acuña Alonzo, Victor
Mendoza Revilla, Javier
Poletti, Giovanni
Quinto Sánchez, Mirsha
Ramallo, Virginia
Adhikari, Kaustubh
Barquera, Rodrigo
Rothhammer, Francisco
Ruiz Linares, Andrés
Schüler Faccini, Lavinia
Silva de Cerqueira, Caio C.
Schmid, Annina B.
Villamil Ramírez, Hugo
Villegas, Valeria

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/43146

Acceso en línea:

https://hdl.handle.net/10495/43146

Palabra clave:

Canal de Sodio Activado por Voltaje NAV1.7 - genética
NAV1.7 Voltage-Gated Sodium Channel - genetics
Hombre de Neandertal - genética
Neanderthals - genetics
Nocicepción
Nociception
Dolor - genética
Pain - genetics
Umbral del Dolor
Pain Threshold
https://id.nlm.nih.gov/mesh/D062556
https://id.nlm.nih.gov/mesh/D059125
https://id.nlm.nih.gov/mesh/D059225
https://id.nlm.nih.gov/mesh/D010146
https://id.nlm.nih.gov/mesh/D017288

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/