Antileishmanial Activity and Cytotoxicity of ent-Beyerene Diterpenoids

We describe the in vitro and in vivo leishmanicidal activity of two diterpenes of the ent-beyerene type, as well as several derivatives. The results indicate that the 18-hydroxymethyl group is essential for the activity. Using in vitro assays, two compounds, 10 and 11, exhibited an EC50 of 1.1 and 1...

Full description

Autores:

Murillo Mosquera, Jilmar Andrés
Gil Romero, Juan Fernando
Upegui Zapata, Yulieth Alexandra
Restrepo Agudelo, Adriana María
Robledo Restrepo, Sara María
Quiñones Fletcher, Winston
Echeverri López, Luis Fernando
Escobar Peláez, Gustavo
San Martin, Aurelio
Olivo, Horacio F.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2019

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/47253

Acceso en línea:

https://hdl.handle.net/10495/47253

Palabra clave:

Línea Celular
Cell Line
Diterpenos
Diterpenes
Leishmania braziliensis
Leishmaniasis Cutánea
Leishmaniasis, Cutaneous
Macrófagos - efectos de los fármacos
Macrophages - drug effects
Mesocricetus
https://id.nlm.nih.gov/mesh/D008647
Tripanocidas
Trypanocidal Agents
https://id.nlm.nih.gov/mesh/D002460
https://id.nlm.nih.gov/mesh/D004224
https://id.nlm.nih.gov/mesh/D007892
https://id.nlm.nih.gov/mesh/D016773
https://id.nlm.nih.gov/mesh/D008264
https://id.nlm.nih.gov/mesh/D014344
ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/4.0/