In Silico, In Vitro, and Pharmacokinetic Studies of UBMC-4, A Potential Novel Compound for Treating against Trypanosoma cruzi

ABSTRACT: : The lack of therapeutic alternatives for the treatment of Chagas disease, a neglected disease, drives the discovery of new drugs with trypanocidal activity. Consequently, we conducted in vitro studies using UBMC-4, a potential Trypanosoma cruzi AKT-like pleckstrin homology (PH) domain in...

Full description

Autores:

Bustamante Toro, Christian
Díez Mejía, Andrés Felipe
Arbeláez Córdoba, Natalia
Robledo Restrepo, Sara María
Ochoa Deossa, Rodrigo Alonso
Marín Villa, Marcel
Varela M., Rubén E.
Soares, Maurilio José

Tipo de recurso:

Article of investigation

Fecha de publicación:

2022

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/44553

Acceso en línea:

https://hdl.handle.net/10495/44553

Palabra clave:

Trypanosoma cruzi
Enfermedad de Chagas
Chagas Disease
Simulación del Acoplamiento Molecular
Molecular Docking Simulation
Descubrimiento de Drogas
Drug Discovery
Farmacocinética
Pharmacokinetics
https://id.nlm.nih.gov/mesh/D014349
https://id.nlm.nih.gov/mesh/D014355
https://id.nlm.nih.gov/mesh/D062105
https://id.nlm.nih.gov/mesh/D055808
https://id.nlm.nih.gov/mesh/D010599

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/