A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia

ABSTRACT: We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation (in 10q26) and three novel loci for eye pigmentation (in 1q32, 20...

Full description

Autores:

Bedoya Berrío, Gabriel de Jesús
Arias Pérez, William Hernán
Jaramillo Alzate, Claudia Milena
Ruíz Linares, Andrés
Mendoza Revilla, Javier
Sohail, Anood
Fuentes Guajardo, Macarena
Lampert, Jodie
Chacón Duque, Juan Camilo
Hurtado, Malena
Villegas, Valeria
Granja, Vanessa
Acuña Alonzo, Víctor
Barquera Lozano, Rodrigo
Everardo, Paola
Gómez Valdés, Jorge
Villamil Ramírez, Hugo
Silva de Cerqueira, Caio C.
Hunemeier, Tábita
Ramallo, Virginia
Schuler Faccini, Lavinia
Salzano, Francisco M.
González José, Rolando
Bortolini, Maria Cátira
Canizales Quinteros, Samuel
Gallo, Carla
Poletti, Giovanni
Rothhammer, Francisco
Tobin, Desmond J.
Fumagalli, Matteo
Balding, David
Adhikari, Kaustubh

Tipo de recurso:

Article of investigation

Fecha de publicación:

2019

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41126

Acceso en línea:

https://hdl.handle.net/10495/41126

Palabra clave:

Biological Evolution
Evolución Biológica
Epistasis, Genetic
Epistasis Genética
Gene Expression
Expresión Génica
Gene Frequency
Frecuencia de los Genes
Genetics, Population
Genética de Población
Genome, Human
Genoma Humano
Genome-Wide Association Study
Estudio de Asociación del Genoma Completo
Guanine Nucleotide Exchange Factors
Factores de Intercambio de Guanina Nucleótido
Membrane Proteins
Proteínas de la Membrana
Membrane Transport Proteins
Proteínas de Transporte de Membrana
Polymorphism, Single Nucleotide
Polimorfismo de Nucleótido Simple
Quantitative Trait Loci
Sitios de Carácter Cuantitativo
Receptor, Metabotropic Glutamate 5
Receptor del Glutamato Metabotropico 5
Skin Pigmentation
Pigmentación de la Piel
Ubiquitin-Protein Ligases
Ubiquitina-Proteína Ligasas
https://id.nlm.nih.gov/mesh/D005075
https://id.nlm.nih.gov/mesh/D004843
https://id.nlm.nih.gov/mesh/D015870
https://id.nlm.nih.gov/mesh/D005787
https://id.nlm.nih.gov/mesh/D005828
https://id.nlm.nih.gov/mesh/D015894
https://id.nlm.nih.gov/mesh/D055106
https://id.nlm.nih.gov/mesh/D020662
https://id.nlm.nih.gov/mesh/D008565
https://id.nlm.nih.gov/mesh/D026901
https://id.nlm.nih.gov/mesh/D020641
https://id.nlm.nih.gov/mesh/D040641
https://id.nlm.nih.gov/mesh/D064529
https://id.nlm.nih.gov/mesh/D012880
https://id.nlm.nih.gov/mesh/D044767

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/