Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

ABSTRACT: Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated with severe EBV disease that renders immunological studies challenging....

Full description

Autores:

Arias Sierra, Andrés Augusto
Laurent, Abel
Al Ali, Fatima
Alkan, Gulsum
Ata, Manar
Béziat, Vivien
Bohlen, Jonathan
Boisson Dupuis, Stéphanie
Bustamante, Jacinta
Casavana, Jean Laurent
Chrabieh, Maya
Emiroğlu, Melike
Fieschi, Claire
Golec, Dominic P.
Hauck, Fabian
Han, Ji Eun
Jouanguy, Emmanuelle
Kaul, Zenia
Khan, Taushif
Kong, Xiao-Fei
Latour, Sylvain
Laine, Candice
Lei, Wei-Te
Martin, Emmanuel
Marr, Nico
Mansouri, Davood
Neven, Bénédicte
Ogishi, Masato
Pelham, Simon J
Parvaneh, Nima
Philippot, Quentin
Pekcan, Sevgi
Rodriguez, Rémy
Rozenberg, Flore
Rao, V Koneti
Schwartzberg, Pamela L.
Seeleuthner, Yoann
Tokgöz, Hüseyin
Uitto, Jouni
Vahidnezhad, Hassan
Yang, Rui
Youssefian, Leila

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/40729

Acceso en línea:

https://hdl.handle.net/10495/40729

Palabra clave:

Interferon-gamma
Interferón gamma
Receptors, Antigen, T-Cell, alpha-beta
Receptores de Antígenos de Linfocitos T alfa-beta
Receptors, Antigen, T-Cell, gamma-delta
Receptores de Antígenos de Linfocitos T gamma-delta
T-Lymphocyte Subsets
Subgrupos de Linfocitos T
Thymus Gland
Timo
Tuberculosis
Tuberculosis
https://id.nlm.nih.gov/mesh/D007371
https://id.nlm.nih.gov/mesh/D016693
https://id.nlm.nih.gov/mesh/D016692
https://id.nlm.nih.gov/mesh/D016176
https://id.nlm.nih.gov/mesh/D013950
https://id.nlm.nih.gov/mesh/D014376

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/