Silencing of CDK5 reduces neurofibrillary tangles in transgenic Alzheimer's mice

Alzheimer’s disease is a major cause of dementia for which treatments remain unsatisfactory. Cyclin-dependent kinase 5 (CDK5) is a relevant kinase that has been hypothesized to contribute to the tau pathology. Several classes of chemical inhibitors for CDK5 have been developed, but they generally la...

Full description

Autores:

Piedrahita, Diego
Hernández, Israel
López Tobón, Alejandro
Gallego Gómez, Juan Carlos
Cardona Gómez, Gloria Patricia
Fedorov, Dmitry
Obara, Boguslaw
Manjunath, B.S.
Boudreau, Ryan L.
LaFerla, Frank
Kosik, Kenneth S.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2010

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/47814

Acceso en línea:

https://hdl.handle.net/10495/47814

Palabra clave:

610 - Medicina y salud
Enfermedad de Alzheimer
Alzheimer Disease
Anticuerpos Monoclonales
Antibodies, Monoclonal
Western Blotting
Blotting, Western
Región CA1 Hipocampal
CA1 Region, Hippocampal
Técnica del Anticuerpo Fluorescente
Fluorescent Antibody Technique
Silenciador del Gen
Gene Silencing
Inmunohistoquímica
Immunohistochemistry
Ratones Endogámicos C57BL
Mice, Inbred C57BL
Ratones Transgénicos
Mice, Transgenic
Ovillos Neurofibrilares
Neurofibrillary Tangles
Proteínas tau
tau Proteins
https://id.nlm.nih.gov/mesh/D000544
https://id.nlm.nih.gov/mesh/D000911
https://id.nlm.nih.gov/mesh/D015153
https://id.nlm.nih.gov/mesh/D056547
https://id.nlm.nih.gov/mesh/D005455
https://id.nlm.nih.gov/mesh/D020868
https://id.nlm.nih.gov/mesh/D007150
https://id.nlm.nih.gov/mesh/D008810
https://id.nlm.nih.gov/mesh/D008822
https://id.nlm.nih.gov/mesh/D016874
https://id.nlm.nih.gov/mesh/D016875
ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades

Rights

openAccess

License

http://creativecommons.org/licenses/by/4.0/