Multitranscript analysis reveals an effect of 2-deoxy-d-glucose on gene expression linked to unfolded protein response and integrated stress response in primary human monocytes and monocyte-derived macrophages

ABSTRACT: Background: Glycolytic inhibitor 2-deoxy-D-glucose (2-DG) binds to hexokinase in a non-competitive manner and phosphoglucose isomerase in a competitive manner, blocking the initial steps of the glycolytic pathway. Although 2-DG stimulates endoplasmic reticulum (ER) stress, activating the u...

Full description

Autores:

Urcuqui Inchima, Silvio
Velilla Hernández, Paula Andrea
Tamayo Molina, Yordi Sebastián
Hernández Sarmiento, Lady Johana

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/35522

Acceso en línea:

https://hdl.handle.net/10495/35522

Palabra clave:

Desoxiglucosa
Deoxyglucose
Estrés del Retículo Endoplásmico
Endoplasmic Reticulum Stress
Respuesta de Proteína Desplegada
Unfolded Protein Response
Glicosilación
Glycosylation
Células
Cells

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/2.5/co/