Phytochemicals and colorectal cancer: About polyphenols
ABSTRACT: Dietary consumption of polyphenols, found in fruits and vegetables, has been associated with a potentially protective role in colorectal cancer (CRC). To establish the state of knowledge regarding advances in polyphenols, CCR and action mechanisms a systematic review and an analysis of inf...
- Autores:
-
Maldonado Celis, María Elena
Guerrero Ospina, Juan Camilo
Restrepo Gallego, Beatriz
Loango Chamorro, Nelsy
Quiñones Landázuri, Mercedes
Landázuri, Patricia
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2024
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/43522
- Acceso en línea:
- https://hdl.handle.net/10495/43522
- Palabra clave:
- Flavonoides
Flavonoids
Apoptosis
Ciclo Celular
Cell Cycle
Polifenoles
Polyphenols
Neoplasias Colorrectales
Colorectal Neoplasms
https://id.nlm.nih.gov/mesh/D005419
https://id.nlm.nih.gov/mesh/D017209
https://id.nlm.nih.gov/mesh/D002453
https://id.nlm.nih.gov/mesh/D059808
https://id.nlm.nih.gov/mesh/D015179
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.spa.fl_str_mv |
Phytochemicals and colorectal cancer: About polyphenols |
| dc.title.translated.spa.fl_str_mv |
Fitoquímicos y cáncer colorrectal: Acerca de los polifenoles |
| title |
Phytochemicals and colorectal cancer: About polyphenols |
| spellingShingle |
Phytochemicals and colorectal cancer: About polyphenols Flavonoides Flavonoids Apoptosis Ciclo Celular Cell Cycle Polifenoles Polyphenols Neoplasias Colorrectales Colorectal Neoplasms https://id.nlm.nih.gov/mesh/D005419 https://id.nlm.nih.gov/mesh/D017209 https://id.nlm.nih.gov/mesh/D002453 https://id.nlm.nih.gov/mesh/D059808 https://id.nlm.nih.gov/mesh/D015179 |
| title_short |
Phytochemicals and colorectal cancer: About polyphenols |
| title_full |
Phytochemicals and colorectal cancer: About polyphenols |
| title_fullStr |
Phytochemicals and colorectal cancer: About polyphenols |
| title_full_unstemmed |
Phytochemicals and colorectal cancer: About polyphenols |
| title_sort |
Phytochemicals and colorectal cancer: About polyphenols |
| dc.creator.fl_str_mv |
Maldonado Celis, María Elena Guerrero Ospina, Juan Camilo Restrepo Gallego, Beatriz Loango Chamorro, Nelsy Quiñones Landázuri, Mercedes Landázuri, Patricia |
| dc.contributor.author.none.fl_str_mv |
Maldonado Celis, María Elena Guerrero Ospina, Juan Camilo Restrepo Gallego, Beatriz Loango Chamorro, Nelsy Quiñones Landázuri, Mercedes Landázuri, Patricia |
| dc.contributor.researchgroup.spa.fl_str_mv |
Impacto de Componentes Alimentarios en la Salud |
| dc.subject.decs.none.fl_str_mv |
Flavonoides Flavonoids Apoptosis Ciclo Celular Cell Cycle Polifenoles Polyphenols Neoplasias Colorrectales Colorectal Neoplasms |
| topic |
Flavonoides Flavonoids Apoptosis Ciclo Celular Cell Cycle Polifenoles Polyphenols Neoplasias Colorrectales Colorectal Neoplasms https://id.nlm.nih.gov/mesh/D005419 https://id.nlm.nih.gov/mesh/D017209 https://id.nlm.nih.gov/mesh/D002453 https://id.nlm.nih.gov/mesh/D059808 https://id.nlm.nih.gov/mesh/D015179 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D005419 https://id.nlm.nih.gov/mesh/D017209 https://id.nlm.nih.gov/mesh/D002453 https://id.nlm.nih.gov/mesh/D059808 https://id.nlm.nih.gov/mesh/D015179 |
| description |
ABSTRACT: Dietary consumption of polyphenols, found in fruits and vegetables, has been associated with a potentially protective role in colorectal cancer (CRC). To establish the state of knowledge regarding advances in polyphenols, CCR and action mechanisms a systematic review and an analysis of information available until 2021 were made. Results indicate that only some polyphenols have in vitro, preclinical and clinical studies. These studies showed that polyphenols will inhibit human CRC cell invasion, migration, metastasis formation, tumor growth. Action mechanisms involve signaling pathways that modulate genes, proteins, markers or cell death inductors, like the AMPK pathway, caspases, Bcl-2, p-Akt, and NF-kB, lysosomal and mitochondrial dysfunction, cellular cycle arrest, among the best known and implied in CRC. Overall, in vitro, preclinical and clinical data on phytochemicals against CRC are still not sufficient and therefore the preventive or therapeutic impacts of dietary phytochemicals on CRC development deserve further research. |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-11-15T21:31:23Z |
| dc.date.available.none.fl_str_mv |
2024-11-15T21:31:23Z |
| dc.date.issued.none.fl_str_mv |
2024 |
| dc.type.spa.fl_str_mv |
Artículo de revisión |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Guerrero Ospina JC, Restrepo B, Loango N, Maldonado-Celis ME, Quiñones Landázuri M, Landázuri PPhytochemicals and colorectal cancer: About polyphenols |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/43522 |
| dc.identifier.doi.none.fl_str_mv |
10.37360/blacpma.24.23.5.43 |
| dc.identifier.eissn.none.fl_str_mv |
0717-7917 |
| identifier_str_mv |
Guerrero Ospina JC, Restrepo B, Loango N, Maldonado-Celis ME, Quiñones Landázuri M, Landázuri PPhytochemicals and colorectal cancer: About polyphenols 10.37360/blacpma.24.23.5.43 0717-7917 |
| url |
https://hdl.handle.net/10495/43522 |
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eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Bol. Latinoam Caribe Plantas. Med. Aromat. |
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705 |
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6 |
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23 |
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Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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22 páginas |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Cooperación Latinoamericana y Caribeña en Plantas Medicinales y Aromáticas |
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Santiago de Chile, Chile |
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Universidad de Antioquia |
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Maldonado Celis, María ElenaGuerrero Ospina, Juan CamiloRestrepo Gallego, BeatrizLoango Chamorro, NelsyQuiñones Landázuri, MercedesLandázuri, PatriciaImpacto de Componentes Alimentarios en la Salud2024-11-15T21:31:23Z2024-11-15T21:31:23Z2024Guerrero Ospina JC, Restrepo B, Loango N, Maldonado-Celis ME, Quiñones Landázuri M, Landázuri PPhytochemicals and colorectal cancer: About polyphenolshttps://hdl.handle.net/10495/4352210.37360/blacpma.24.23.5.430717-7917ABSTRACT: Dietary consumption of polyphenols, found in fruits and vegetables, has been associated with a potentially protective role in colorectal cancer (CRC). To establish the state of knowledge regarding advances in polyphenols, CCR and action mechanisms a systematic review and an analysis of information available until 2021 were made. Results indicate that only some polyphenols have in vitro, preclinical and clinical studies. These studies showed that polyphenols will inhibit human CRC cell invasion, migration, metastasis formation, tumor growth. Action mechanisms involve signaling pathways that modulate genes, proteins, markers or cell death inductors, like the AMPK pathway, caspases, Bcl-2, p-Akt, and NF-kB, lysosomal and mitochondrial dysfunction, cellular cycle arrest, among the best known and implied in CRC. Overall, in vitro, preclinical and clinical data on phytochemicals against CRC are still not sufficient and therefore the preventive or therapeutic impacts of dietary phytochemicals on CRC development deserve further research.RESUMEN: El consumo dietético de polifenoles, que se encuentran en frutas y verduras, se ha asociado con un papel potencialmente protector contra el cáncer colorrectal (CCR). Para establecer el estado del conocimiento respecto a los avances en polifenoles, CCR y mecanismos de acción, se realizó una revisión sistemática y un análisis de la información disponible hasta el año 2021. Los resultados indican que sólo algunos polifenoles cuentan con estudios in vitro, preclínicos y clínicos. Estos estudios demostraron que los polifenoles inhiben la invasión, migración, formación de metástasis y crecimiento de tumores de células de CCR humanas. Los mecanismos de acción involucran vías de señalización que modulan genes, proteínas, marcadores o inductores de muerte celular, como la vía AMPK, caspasas, Bcl-2, p-Akt y NF- kB, disfunción lisosomal y mitocondrial, parada del ciclo celular, entre los más conocidos e implicados en el CCR. En general, los datos in vitro, preclínicos y clínicos sobre fitoquímicos contra el CCR aún no son suficientes y, por lo tanto, los impactos preventivos o terapéuticos de los fitoquímicos dietéticos en el desarrollo del CCR requieren más investigación.Colombia. Ministerio de Ciencia, Tecnología e Innovación - MinCienciasCOL008381122 páginasapplication/pdfengCooperación Latinoamericana y Caribeña en Plantas Medicinales y AromáticasSantiago de Chile, Chilehttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-sa/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Phytochemicals and colorectal cancer: About polyphenolsFitoquímicos y cáncer colorrectal: Acerca de los polifenolesArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionFlavonoidesFlavonoidsApoptosisCiclo CelularCell CyclePolifenolesPolyphenolsNeoplasias ColorrectalesColorectal Neoplasmshttps://id.nlm.nih.gov/mesh/D005419https://id.nlm.nih.gov/mesh/D017209https://id.nlm.nih.gov/mesh/D002453https://id.nlm.nih.gov/mesh/D059808https://id.nlm.nih.gov/mesh/D015179Bol. Latinoam Caribe Plantas. Med. 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