Polymorphisms of the CYP2D6 gene and its relationship with Plasmodium vivax relapses after chloroquine-primaquine treatment in Turbo, Colombia

Background: Plasmodium vivax relapse due to hypnozoites represents a significant mechanism for parasite persistence in the population. Primaquine (PQ), the drug of choice for eliminating hypnozoites, requires metabolic activation by Cytochrome P450-2D6 (CYP2D6). Genetic variations in CYP2D6 can alte...

Full description

Autores:

Sierra Cifuentes, Veronica
Zuluaga Idárraga, Lina María
Aguirre Acevedo, Daniel Camilo
Silva de Barros Puça, María Carolina
Nobrega de Sousa, Tais
Lopera Mesa, Tatiana María

Tipo de recurso:

Article of investigation

Fecha de publicación:

2025

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/46861

Acceso en línea:

https://hdl.handle.net/10495/46861

Palabra clave:

Citocromo P-450 CYP2D6
Cytochrome P-450 CYP2D6
Malaria
Sistema Enzimático del Citocromo P-450
Cytochrome P-450 Enzyme System
Plasmodium vivax
Primaquina
Primaquine
Recurrencia
Recurrence
https://id.nlm.nih.gov/mesh/D019389
https://id.nlm.nih.gov/mesh/D008288
http://id.nlm.nih.gov/mesh/D003577
https://id.nlm.nih.gov/mesh/D010966
https://id.nlm.nih.gov/mesh/D011319
http://id.nlm.nih.gov/mesh/D012008

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/4.0/