Interactions of human serum albumin with phosphate and Tris buffers: impact on paclitaxel binding and nanoparticles self-assembly

ABSTRACT: Aim: To investigate the conformational changes in human serum albumin (HSA) caused by chemical (CD) and thermal denaturation (TD) at pH 7.4 and 9.9, crucial for designing controlled drug delivery systems with paclitaxel (PTX). Methods: Experimental and computational methods, including diff...

Full description

Autores:

González Posada, Alexa Hibet
Mesa Cadavid, Mónica
Sierra García, Ligia
López Osorio, Betty Lucy

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/42372

Acceso en línea:

https://hdl.handle.net/10495/42372

Palabra clave:

Albúmina Sérica Humana
Serum Albumin, Human
Desnaturalización Proteica
Protein Denaturation
Paclitaxel Unido a Albúmina
Albumin-Bound Paclitaxel
Paclitaxel
https://id.nlm.nih.gov/mesh/D000075462
https://id.nlm.nih.gov/mesh/D011489
https://id.nlm.nih.gov/mesh/D000068196
https://id.nlm.nih.gov/mesh/D017239

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/2.5/co/