Hypomorphic Notch 3 Alleles Link Notch Signaling to Ischemic Cerebral Small-vessel Disease
ABSTRACT: The most common monogenic cause of small-vessel disease leading to ischemic stroke and vascular dementia is the neurodegenerative syndrome cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is associated with mutations in the Notch 3...
- Autores:
-
Arboleda Velásquez, Joseph Fitzgerald
Manent, Jan
Lee, Jeong Hyun
Tikka, Saara
Ospina Villegas, Carolina
Vanderburg, Charles
Frosch, Matthew Philip
Villen, Judit
Gygi, Steven
Lopera Restrepo, Francisco Javier
Kalimo, Hannu
Moskowitz, Michael Arthur
Ayata, Cenk
Louvi, Angeliki
Artavanis Tsakonas, Spyros
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/35049
- Acceso en línea:
- https://hdl.handle.net/10495/35049
- Palabra clave:
- Ischemic Stroke
Accidente Cerebrovascular Isquémico
Receptor, Notch3
Receptor Notch3
Mutation
Mutación
CADASIL
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/