Screening of the antileishmanial and antiplasmodial potential of synthetic 2-arylquinoline analogs

ABSTRACT: In this study, six analogs of 2-arylquinoline were synthesized and evaluated for their in vitro and in vivo antiplasmodial and leishmanicidal activity. At a later stage, hemolytic activity and druggability were tested in vitro and in silico, respectively, observing as a result: firstly, co...

Full description

Autores:

Robledo Restrepo, Sara María
Espinosa Sáez, Roger
Pineda, Tatiana
Murillo, Javier
Zúñiga, César
Yañez, Osvaldo
Cantero López, Plinio
Sáez Vega, Alex
Guzmán Teran, Camilo

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/43580

Acceso en línea:

https://hdl.handle.net/10495/43580

Palabra clave:

Antimaláricos
Antimalarials
Antiprotozoarios
Antiprotozoal Agents
Leishmania
Simulación del Acoplamiento Molecular
Molecular Docking Simulation
Relación Estructura-Actividad
Structure-Activity Relationship
https://id.nlm.nih.gov/mesh/D000962
https://id.nlm.nih.gov/mesh/D000981
https://id.nlm.nih.gov/mesh/D007891
https://id.nlm.nih.gov/mesh/D062105
https://id.nlm.nih.gov/mesh/D013329

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/