Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer’s disease

ABSTRACT: Recent evidence suggests that rare genetic variants within the TREM2 gene are associated with increased risk of Alzheimer’s disease. TREM2 mutations are the genetic basis for a condition characterized by polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) a...

Full description

Autores:

Giraldo Chica, Margarita María
Lopera Restrepo, Francisco Javier
Carvajal Castrillón, Julián
Muñoz Zapata, Claudia Cecilia
Siniard, Ashley L.
Corneveaux, Jason J.
Schrauwen, Isabelle
Ramirez Restrepo, Manuel
Gaiteri, Chris
Myers, Amanda J.
Caselli, Richard J.
Kosik, Kenneth S.
Reiman, Eric M.
Huentelman, Matthew J.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2013

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/37263

Acceso en línea:

https://hdl.handle.net/10495/37263

Palabra clave:

Enfermedad de Alzheimer
Alzheimer Disease
Conducta - fisiología
Behavior - physiology
Degeneración Lobar Frontotemporal
Frontotemporal Lobar Degeneration
Estudios de Cohortes
Cohort Studies
Glicoproteínas de Membrana
Membrane Glycoproteins
Mutación
Mutation
Receptores Inmunológicos
Receptors, Immunologic
Factores de Riesgo
Risk Factors

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc-nd/4.0/