Response to Rotenone Is Glucose-Sensitive in a Model of Human Acute Lymphoblastic Leukemia: Involvement of Oxidative Stress Mechanism, DJ-1, Parkin, and PINK-1 Proteins

ABSTRACT: To establish the effect of low (11 mM) and high (55 mM) glucose concentrations (G11, G55) on Jurkat cells exposed to rotenone (ROT, a class 5 mitocan). We demonstrated that ROT induces apoptosis in Jurkat cells cultured in G11 by oxidative stress (OS) mechanism involving the generation of...

Full description

Autores:

Mendivil Pérez, Miguel Ángel
Jiménez del Río, Marlene
Vélez Pardo, Carlos Alberto

Tipo de recurso:

Article of investigation

Fecha de publicación:

2014

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/38549

Acceso en línea:

https://hdl.handle.net/10495/38549

Palabra clave:

Apoptosis
Caspase 3
Peróxido de Hidrógeno
Hydrogen Peroxide
Forma del Núcleo Celular - efectos de los fármacos
Cell Nucleus Shape - drug effects
Activación Enzimática - efectos de los fármacos
Enzyme Activation - drug effects
Péptidos y Proteínas de Señalización Intracelular
Intracellular Signaling Peptides and Proteins
Membrane Potential, Mitochondrial - drug effects
Membrane Potential, Mitochondrial - drug effects
Leucemia-Linfoma Linfoblástico de Células Precursoras
Precursor Cell Lymphoblastic Leukemia-Lymphoma
https://id.nlm.nih.gov/mesh/D017209
https://id.nlm.nih.gov/mesh/D053148
https://id.nlm.nih.gov/mesh/D006861
https://id.nlm.nih.gov/mesh/D053144
https://id.nlm.nih.gov/mesh/D004789
https://id.nlm.nih.gov/mesh/D047908
https://id.nlm.nih.gov/mesh/D053078
https://id.nlm.nih.gov/mesh/D054198

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/