Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages

ABSTRACT: Interferons (IFNs) are a family of cytokines that activate the JAK-STAT signaling pathway to induce an antiviral state in cells. Interleukin 27 (IL-27) is a member of the IL-6 and/or IL-12 family that elicits both pro- and anti-inflammatory responses. Recent studies have reported that IL-2...

Full description

Autores:

Valdés López, Juan Felipe
Hernández Sarmiento, Lady Johana
Tamayo Molina, Yordi Sebastián
Velilla Hernández, Paula Andrea
Urcuqui Inchima, Silvio
Rodenhuis Zybert, Izabela A.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41430

Acceso en línea:

https://hdl.handle.net/10495/41430

Palabra clave:

Células Cultivadas
Cells, Cultured
Interleucina-27
Interleukin-27
Fiebre Chikungunya
Chikungunya Fever
Virus Chikungunya
Chikungunya virus
Virus del Dengue
Dengue Virus
Dengue
Interferones
Interferons
Interleucinas
Interleukins
Quinasas Janus
Janus Kinases
Macrófagos
Macrophages
Factores de Transcripción STAT
STAT Transcription Factors
Transducción de Señal
Signal Transduction
Replicación Viral
Virus Replication
https://id.nlm.nih.gov/mesh/D002646
https://id.nlm.nih.gov/mesh/D002478
https://id.nlm.nih.gov/mesh/D064094
https://id.nlm.nih.gov/mesh/D065632
https://id.nlm.nih.gov/mesh/D003716
https://id.nlm.nih.gov/mesh/D003715
https://id.nlm.nih.gov/mesh/D007372
https://id.nlm.nih.gov/mesh/D007378
https://id.nlm.nih.gov/mesh/D053612
https://id.nlm.nih.gov/mesh/D008264
https://id.nlm.nih.gov/mesh/D050791
https://id.nlm.nih.gov/mesh/D015398
https://id.nlm.nih.gov/mesh/D014779

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/