Helper T cell immunity in humans with inherited CD4 deficiency

ABSTRACT: CD4+ T cells are vital for host defense and immune regulation. However, the fundamental role of CD4 itself remains enigmatic. We report seven patients aged 5–61 years from five families of four ancestries with autosomal recessive CD4 deficiency and a range of infections, including recalcit...

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Autores:

Moncada Vélez, Marcela
Franco Restrepo, José Luis
Vélez Ortega, Alejandra Catalina
Rojas Restrepo, Jessica Lineth
Orrego Arango, Julio César
García Moreno, Luis Fernando
Marín Agudelo, Nancy Dora
Guérin, Antoine
Jackson, Katherine
Ogishi, Masato
Rosain, Jérémie
Mancini, Mathieu
Nunez, Andrea
Webster, Samantha
Goyette, Jesse
Khan, Taushif
Marr, Nico
Avery, Danielle T.
Rao, Geetha
Waterboer, Tim
Michels, Birgitta
Neves, Esmeralda
Morais, Cátia Iracema
London, Jonathan
Quartier dit Maire, Pierre
Mestrallet, Stéphanie
Neven, Bénédicte
Rapaport, Franck
Seeleuthner, Yoann
Lev, Atar
Simon, Amos J.
Montoya, Jorge
Barel, Ortal
L’Honneur, Anne Sophie
Soudée, Camille
Sereti, Irini
Terrier, Benjamin
Abel, Laurent
Boisson Dupuis, Stéphanie
Reis, Joel
Marinho, Antonio
Lisco, Andrea
Faria, Emilia
Goodnow, Christopher C.
Vasconcelos, Julia
Béziat, Vivien
Ma, Cindy S.
Somech, Raz
Casanova, Jean Laurent
Bustamante, Jacinta
Tangye, Stuart G.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/43137

Acceso en línea:

https://hdl.handle.net/10495/43137

Palabra clave:

Linfocitos T CD4-Positivos
CD4-Positive T-Lymphocytes
Linfocitos T CD8-positivos
CD8-Positive T-Lymphocytes
Antígenos HLA
HLA Antigens
Activación de Linfocitos
Lymphocyte Activation
Isoformas de Proteínas - metabolismo
Protein Isoforms - metabolism
Linfocitos T Colaboradores-Inductores
T-Lymphocytes, Helper-Inducer
https://id.nlm.nih.gov/mesh/D015496
https://id.nlm.nih.gov/mesh/D018414
https://id.nlm.nih.gov/mesh/D006680
https://id.nlm.nih.gov/mesh/D008213
https://id.nlm.nih.gov/mesh/D020033
https://id.nlm.nih.gov/mesh/D006377

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/