Key amino acid residues involved in mammalian and insecticidal activities of Magi4 and Hv1b, cysteine‑rich spider peptides from the δ‑atracotoxin family

ABSTRACT: δ-Atracotoxins, also known as δ-hexatoxins, are spider neurotoxic peptides, lethal to both vertebrates and insects. Their mechanism of action involves the binding to of the S3/S4 loop of the domain IV of the voltage-gated sodium channels (Nav). Because of the chemical difculties of synthes...

Full description

Autores:

Corrales García, Ligia Luz
Borrego, Jesús
Clement, Herlinda
Arenas, Iván
Corzo, Gerardo

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/38215

Acceso en línea:

https://hdl.handle.net/10495/38215

Palabra clave:

Secuencias de Aminoácidos
Amino Acid Motifs
Secuencia de Aminoácidos - genética
Amino Acid Sequence - genetics
Sustitución de Aminoácidos - genética
Amino Acid Substitution - genetics
Aminoácidos - genética
Amino Acids - genetics
Gryllidae
Insecticidas - química
Insecticides - chemistry
Insecticidas - toxicidad
Insecticides - toxicity
Dosificación Letal Mediana
Lethal Dose 50
Ratones
Mice
Neurotoxinas
Neurotoxins
Dominios Proteicos
Protein Domains
Proteínas Recombinantes
Recombinant Proteins
Venenos de Araña
Spider Venoms
https://id.nlm.nih.gov/mesh/D000596
https://id.nlm.nih.gov/mesh/D006135
https://id.nlm.nih.gov/mesh/D020816
https://id.nlm.nih.gov/mesh/D019943
https://id.nlm.nih.gov/mesh/D007306
https://id.nlm.nih.gov/mesh/D007928
https://id.nlm.nih.gov/mesh/D051379
https://id.nlm.nih.gov/mesh/D009498
https://id.nlm.nih.gov/mesh/D000072417
https://id.nlm.nih.gov/mesh/D011994
https://id.nlm.nih.gov/mesh/D013111

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/