Germline Mutations in PALB2, BRCA1, and RAD51C, wich Regulate DNA Recombination Repair, in Patients with Gastric Cancer

ABSTRACT: Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) n...

Full description

Autores:

González Castrillón, Luz María
Cock Rada, Alicia María
Bohorquez Lozano, Mabel Elena
Toa, Ted
Estrada Flórez, Ana Patricia
Suárez Olaya, John Jairo
Brea Fernández, Alejandro
Cameselle Teijeiro, José
Pinto, Carla
Ramos, Irma
Mantilla Morales, Alejandra
Prieto Sánchez, Rodrigo
Corvalán, Alejandro
Norero, Enrique
Álvarez, Carolina
Tapia, Teresa
Carvallo, Pilar
Sahasrabudhe, Ruta
Lott, Paul
Solano, Angela
Neffa, Florencia
Della Valle, Adriana
Yau, Chris
Soares, Gabriela
Borowsky, Alexander
Hu, Nan
He, Li-Ji
Han, Xiao-You
Taylor, Philip R.
Goldstein, Alisa M.
Torres, Javier
Echeverry De Polanco, María Magdalena
Ruiz Ponte, Clara
Rodrigues Teixeira, Manuel António
Carvajal Carmona, Luis Guillermo

Tipo de recurso:

Article of investigation

Fecha de publicación:

2017

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/34012

Acceso en línea:

https://hdl.handle.net/10495/34012

Palabra clave:

Stomach
Estómago
Stomach Neoplasms
Neoplasias Gástricas
Whole Exome Sequencing
Secuenciación del Exoma Completo
Fanconi Anemia Complementation Group N Protein
Proteína del Grupo de Complementación N de la Anemia de Fanconi
BRCA1 Protein
Proteína BRCA1
Recombinational DNA Repair
Reparación del ADN por Recombinación

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/2.5/co/