Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia

ABSTRACT: We describe in vivo follow-up PET imaging and postmortem findings from an autosomal dominant Alzheimer's disease (ADAD) PSEN1 E280A carrier who was also homozygous for the APOE3 Christchurch (APOE3ch) variant and was protected against Alzheimer's symptoms for almost three decades...

Full description

Autores:

Aguillón Niño, David Fernando
Quiroz Gaviria, Yakeel Tatiana
Baena, Ana
Sepulveda Falla, Diego Alonso
Lopera Restrepo, Francisco Javier
Almeida, María Camila
Boassa, Daniela
Acosta Uribe, Juliana
Vila Castelar, Clara
Ramírez Gómez, Liliana
Sánchez, Justin S.
Villalba Moreno, Nelson David
Littau, Jessica Lisa
Villegas Lanau, Carlos Andrés
Beach, Thomas G.
White 3rd, Charles L.
Ellisman, Mark
Krasemann, Susanne
Glatzel, Markus
Johnson, Keith A.
Sperling, Reisa A.
Reiman, Eric M.
Arboleda Velásquez, Joseph Fitzgerald
Kosik, Kenneth S.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2022

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/42134

Acceso en línea:

https://hdl.handle.net/10495/42134

Palabra clave:

Alzheimer Disease
Enfermedad de Alzheimer
Amyloid beta-Peptides
Péptidos beta-Amiloides
Apolipoprotein E3
Apolipoproteína E3
Brain
Éncefalo
Homozygote
Homocigoto
Positron-Emission Tomography
Tomografía de Emisión de Positrones
tau Proteins
Proteínas tau
https://id.nlm.nih.gov/mesh/D000544
https://id.nlm.nih.gov/mesh/D016229
https://id.nlm.nih.gov/mesh/D053318
https://id.nlm.nih.gov/mesh/D001921
https://id.nlm.nih.gov/mesh/D006720
https://id.nlm.nih.gov/mesh/D049268
https://id.nlm.nih.gov/mesh/D016875

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/