The Alzheimer’s Prevention Initiative composite cognitive test score: Sample size estimates for the evaluation of preclinical Alzheimer’s disease treatments in presenilin 1 E280A mutation carriers

Objective— There is a need to identify a cognitive composite that is sensitive to tracking preclinical AD decline to be used as a primary endpoint in treatment trials. Method— We capitalized on longitudinal data, collected from 1995 to 2010, from cognitively unimpaired presenilin 1 (PSEN1) E280A mut...

Full description

Autores:

Lopera Restrepo, Francisco Javier
Napatkamon Ayutyanont
Langbaum, Jessica B.
Hendrix, Suzanne B.
Fleisher, Adam S.
Friesenhahn, Michel
Ward, Michael
Aguirre Acevedo, Daniel Camilo
Acosta Baena, Natalia
Madrigal Zapata, Lucía del Socorro
Muñoz, Claudia
Tirado Pérez, Victoria Claudia
Moreno Masmela, Sonia
Chen, Kewei
Tariot, Pierre N.
Reiman, Eric M.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2014

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/47901

Acceso en línea:

https://hdl.handle.net/10495/47901

Palabra clave:

610 - Medicina y salud
Enfermedad de Alzheimer
Alzheimer Disease
Aberraciones Cromosómicas
Chromosome Aberrations
Análisis Mutacional de ADN
DNA Mutational Analysis
Progresión de la Enfermedad
Disease Progression
Genes Dominantes
Genes, Dominant
Tamización de Portadores Genéticos
Genetic Carrier Screening
Predisposición Genética a la Enfermedad
Genetic Predisposition to Disease
Presenilina-1
Presenilin-1
https://id.nlm.nih.gov/mesh/D000544
https://id.nlm.nih.gov/mesh/D002869
https://id.nlm.nih.gov/mesh/D004252
https://id.nlm.nih.gov/mesh/D018450
https://id.nlm.nih.gov/mesh/D005799
https://id.nlm.nih.gov/mesh/D006580
https://id.nlm.nih.gov/mesh/D020022
https://id.nlm.nih.gov/mesh/D053764
ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades

Rights

openAccess

License

http://purl.org/coar/access_right/c_abf2