Triclosan-caffeic acid hybrids: Synthesis, leishmanicidal, trypanocidal and cytotoxic activities

ABSTRACT: The synthesis, cytotoxicity, anti-leishmanial and anti-trypanosomal activities of twelve triclosan-caffeic acid hybrids are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric analyses. The synthesized compounds were evaluated agains...

Full description

Autores:

Otero Tejada, Elver Luis
García Carvajal, Elisa
Palacios Cortés, Genesis
Yepes Daza, Lina Marcela
Carda, Miguel
Agut, Raúl
Vélez Bernal, Iván Darío
Cardona Galeano, Wilson
Robledo Restrepo, Sara María

Tipo de recurso:

Article of investigation

Fecha de publicación:

2017

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41792

Acceso en línea:

https://hdl.handle.net/10495/41792

Palabra clave:

Antiprotozoarios
Antiprotozoal Agents
Ácidos Cafeicos
Caffeic Acids
Leishmaniasis
Línea Celular
Cell Line
Relación Dosis-Respuesta a Droga
Dose-Response Relationship, Drug
Leishmania
Macrófagos
Macrophages
Triclosán
Triclosan
Trypanosoma cruzi
Enfermedad de Chagas
Chagas Disease
Pruebas de Sensibilidad Parasitaria
Parasitic Sensitivity Tests
Relación Estructura-Actividad
Structure-Activity Relationship
https://id.nlm.nih.gov/mesh/D000981
https://id.nlm.nih.gov/mesh/D002109
https://id.nlm.nih.gov/mesh/D007896
https://id.nlm.nih.gov/mesh/D002460
https://id.nlm.nih.gov/mesh/D004305
https://id.nlm.nih.gov/mesh/D007891
https://id.nlm.nih.gov/mesh/D008264
https://id.nlm.nih.gov/mesh/D014260
https://id.nlm.nih.gov/mesh/D014349
https://id.nlm.nih.gov/mesh/D014355
https://id.nlm.nih.gov/mesh/D021261
https://id.nlm.nih.gov/mesh/D013329

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc-nd/4.0/