Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic (DAergic) neurons in the substantia nigra and the intraneuronal presence of Lewy bodies (LBs), composed of aggregates of phosphorylated alpha-synuclein at residue Ser129 (p-Ser129α-Syn). Unfo...

Full description

Autores:

Pérez Abshana, Laura Patricia
Mendívil Pérez, Miguel Ángel
Vélez Pardo, Carlos Alberto
Jiménez del Río, Marlene

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/46455

Acceso en línea:

https://hdl.handle.net/10495/46455

Palabra clave:

Glucosilceramidasa - Genética
Glucosylceramidase - Genetics
Neuronas Dopaminérgicas
Dopaminergic Neurons
Rotenona
Rotenone
Células HEK293
HEK293 Cells
Proteína 2 Quinasa Serina - Treonina Rica en Repeticiones de Leucina
Leucine-Rich Repeat Serine - Threonine Protein Kinase-2
Peróxido de Hidrógeno
Hydrogen Peroxide
alfa-Sinucleína
alpha-Synuclein
Enfermedad de Parkinson
Parkinson disease
https://id.nlm.nih.gov/mesh/D005962
https://id.nlm.nih.gov/mesh/D059290
https://id.nlm.nih.gov/mesh/D012402
https://id.nlm.nih.gov/mesh/D057809
https://id.nlm.nih.gov/mesh/D000071158
https://id.nlm.nih.gov/mesh/D006861
https://id.nlm.nih.gov/mesh/D051844
ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades

Rights

openAccess

License

http://creativecommons.org/licenses/by/4.0/